84224-29-3

Basic information

• Product Name: 4-hydroxy-2-methoxybenzonitrile
• Synonyms: 4-hydroxy-2-methoxybenzonitrile;4-Cyano-3-methoxyphenol
• CAS NO: 84224-29-3
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Mol File: 84224-29-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-hydroxy-2-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2-methoxybenzonitrile(84224-29-3)
• EPA Substance Registry System: 4-hydroxy-2-methoxybenzonitrile(84224-29-3)

Safety Data

• Hazardous Substances Data: 84224-29-3(Hazardous Substances Data)

Usage

General Description

4-hydroxy-2-methoxybenzonitrile is a chemical compound with the molecular formula C8H7NO2. It is an organic compound classified as a benzonitrile derivative, and it has a hydroxy and methoxy group attached to a benzene ring. 4-hydroxy-2-methoxybenzonitrile is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds due to its versatile reactivity and functional groups. It is also used as an intermediate in the manufacturing of dyes, pigments, and other specialty chemicals. Additionally, 4-hydroxy-2-methoxybenzonitrile has shown potential biological activities, making it of interest in medicinal and biochemical research. Overall, this compound plays a significant role in the chemical and pharmaceutical industries due to its diverse applications and reactivity.

Upstream product

• 2942-58-7 diethyl cyanophosphonate 
• 2880-58-2 2-methoxy-1,4-benzoquinone 
• 4107-65-7 2,4-dimethoxybenzonitrile 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 90111-34-5 4-hydroxy-2-methoxybenzoic acid 
• 330793-38-9 4-bromo-2-methoxybenzonitrile 
• 84224-28-2 4-hydroxy-2-methoxybenzamide 
• 18278-34-7 4-hydroxy-2-methoxybenzaldehyde 
• 155912-31-5 4-hydroxy-2-methoxy-benzaldehyde-oxime 
• 108-24-7 acetic anhydride 
• 101714-11-8 5-cyano-2-hydroxy-4-methoxy-benzoic acid 

Downstream Products

• 1187026-36-3 C₁₁H₁₂N₂O₂S 
• 84223-69-8 2,2'-Dimethoxy-4,4'-pentamethylendioxydibenzonitril 

Relevant articles and documents

Photoinduced Hydroxylation of Organic Halides under Mild Conditions

Presented in this paper is photoinduced hydroxylation of organic halides, providing a mild access to a range of functionalized phenols and aliphatic alcohols. These reactions generally proceed under mild reaction conditions with no need for a photocatalyst or a strong base and show a wide substrate scope as well as excellent functional group tolerance. This work highlights the unique role of NaI that allows a challenging transformation to proceed under mild reaction conditions.

THIOPHENE DERIVATIVES AS AGONISTS OF S1P1/EDG1

The invention relates to novel thiophene derivatives (1), their preparation and their use as pharmaceutically active compounds.Said compounds particularly act as immunomodulating agents. Formula (I).

Compounds useful in therapy

Compounds of formula (I), [image] or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii) one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6 alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.