84227-68-9 Usage
Uses
Used in Chemical Reactions:
N-[2-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE is used as a catalyst to facilitate and expedite the progress of various chemical reactions. Its effectiveness in this role stems from its ability to lower the activation energy required for reactions to proceed, thereby increasing the reaction rate and improving overall efficiency.
Used in Pharmaceutical Production:
In the pharmaceutical industry, N-[2-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE is utilized as a key intermediate in the synthesis of various drugs. Its unique chemical structure allows it to participate in the formation of complex organic molecules, contributing to the development of new and innovative medications.
Used in Dye Production:
N-[2-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE also finds application in the dye industry, where it is employed in the synthesis of different types of dyes. Its chemical properties enable it to contribute to the creation of vibrant and stable colorants used in various applications, including textiles, printing, and plastics.
Used in Research and Development:
Due to its reactivity and versatility, N-[2-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE is a valuable compound in research and development settings. It is used in the exploration of new chemical pathways and the discovery of novel compounds with potential applications in various fields.
Safety Considerations:
Given its potential health hazards, including skin and eye irritation, N-[2-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE should be handled with care. Proper safety protocols, including the use of personal protective equipment and adherence to material safety data sheets, are essential to minimize risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 84227-68-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,2,2 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 84227-68:
(7*8)+(6*4)+(5*2)+(4*2)+(3*7)+(2*6)+(1*8)=139
139 % 10 = 9
So 84227-68-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H20N2/c1-3-14(4-2)10-12-8-6-5-7-11(12)9-13/h5-8H,3-4,9-10,13H2,1-2H3
84227-68-9Relevant academic research and scientific papers
Selective butyrylcholine esterase inhibitor or pharmaceutically acceptable salt thereof, and preparation method and application thereof
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Paragraph 0037; 0040-0041, (2020/01/12)
The invention discloses a selective butyrylcholine esterase inhibitor represented by a general formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method and an application thereof. Butyrylcholine esterase inhibitory activity, sel
Synthesis of new 4-Aminoquinolines and evaluation of their in vitro activity against chloroquine-sensitive and chloroquine-resistant plasmodium falciparum
Rajapakse, Chandima S.K.,Lisai, Maryna,Deregnaucourt, Christiane,Sinou, Véronique,Latour, Christine,Roy, Dipankar,Schrével, Joseph,Sánchez-Delgado, Roberto A.
, (2015/12/18)
The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-Aminoquinolines known and remains effective against chloroquineresistant parasites, but toxicity issues linked to a quinone-imine metabolite limit its clinical use. In search of new compounds able to retain the antimalarial activity of amodiaquine while circumventing quinone-imine metabolite toxicity, we have synthesized five 4-Aminoquinolines that feature rings lacking hydroxyl groups in the side chain of the molecules and are thus incapable of generating toxic quinone-imines. The new compounds displayed high in vitro potency (low nanomolar IC50), markedly superior to chloroquine and comparable to amodiaquine, against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum, accompanied by low toxicity to L6 rat fibroblasts and MRC5 human lung cells, and metabolic stability comparable or higher than that of amodiaquine. Computational studies indicate a unique mode of binding of compound 4 to heme through the HOMO located on a biphenyl moeity, which may partly explain the high antiplasmodial activity observed for this compound.
