84228-97-7

Basic information

• Product Name: methyl 2-benzylsulfonyl-3-methylbutyrate
• Synonyms: methyl 2-benzylsulfonyl-3-methylbutyrate
• CAS NO: 84228-97-7
• Molecular Weight: 270.35
• Mol File: 84228-97-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-benzylsulfonyl-3-methylbutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzylsulfonyl-3-methylbutyrate(84228-97-7)
• EPA Substance Registry System: methyl 2-benzylsulfonyl-3-methylbutyrate(84228-97-7)

Safety Data

• Hazardous Substances Data: 84228-97-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 82236-52-0 benzyl 2-benzylsulfonyl-3-methylbutyrate 

Downstream Products

• 503-74-2 3-methylbutyric acid 

Relevant articles and documents

New Methods and Reagents in Organic Synthesis. 26. Reductive Desulfonylation of α-Sulfonylacetates

α-Acyl-benzylsulfonyldiazomethanes (2a-d) have been converted to α-benzylsulfonyl-α-substituted-acetic acids (7a-d) by means of the Wolff rearrangement.Reductive removal of the benzylsulfonyl group of 7b-d can be achieved by the use of sodium-ethanol in tetrahydrofuran. α-Benzylsulfonyl-α-substituted-propionic acids (9a-d), prepared from benzyl α-benzylsulfonyl-α-substituted-acetates (3a-d), were also debenzylsulfonylated under similar reductive conditions.The overall process, in combination with the Arndt-Eistert synthesis of α-sulfonylacetates from acyl chlorides and benzylsulfonyldiazomethane (1), provides a new, safe method for the homologation of carboxylic acids.Keywords-reductive desulfonylation; Wolff rearrangement; sodium amalgam reduction; catalytic debenzylation; sodium-ethanol reduction; methylation; α-substituted propionic acid; α-sulfonylacetate