84243-56-1Relevant articles and documents
1,4-DIHYDROPYRIDINE DERIVATIVES
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, (2008/06/13)
A 1,4-dihydropyridine derivative having the formula (I): wherein, R1represents a substituted or unsubstituted phenyl or heterocyclic group, R2represents a C1to C5lower alkyl group, R3represents a substituted or unsubstituted C2to C8alkyl, alkenyl, alkynyl or substituted or unsubstituted cycloalkyl group, R4represents -A-R5, wherein A represents a C2to C8alkylene group or a substituted or unsubstituted C2to C8alkenylene group, and R5represents a substituted or unsubstituted pyridyl, pyridylcarbonyl or piperadinyl group and a drug for overcoming resistance to an anti-cancer drug or a drug increasing the effect of an anti-cancer drug containing as an effective ingredient the derivative or its pharmacologically acceptable salt or hydrate.
Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents
Sircar, Ila,Duell, Bradley L.,Bobowski, George,Bristol, James A.,Evans, Dale B.
, p. 1405 - 1413 (2007/10/02)
A series of 4,5-dihydro-6--3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we