84253-21-4

Upstream product

• 824-55-5 2,4-dimethyl-benzyl chloride 
• 103-16-2 4-Benzyloxyphenol 
• 84253-17-8 benzyl and 2,4-dimethylbenzyl ether of hydroquinone 

Downstream Products

• 123-31-9 hydroquinone 

Relevant academic research and scientific papers

Pd/C-catalyzed chemoselective hydrogenation in the presence of a phenolic MPM protective group using pyridine as a catalyst poison

Employment of a Pd/C-pyridine combination as a catalyst is a very useful method for the selective removal (hydrogenolysis) of phenolic O-benzyl, N-Cbz and benzyl ester protective groups and for the selective hydrogenation of nitro and olefin functions of phenol derivatives protected with the MPM group. These discriminatory results are apparently attributable to the effect of pyridine. The MPM group could be extensively applied to chemoselective hydrogenation as a protective group for phenolic hydroxyl functions.

Chemoselective inhibition of the hydrogenolysis of the MPM protective group for phenolic hydroxy functions using a Pd/C-pyridine catalyst

A convenient method for the selective hydrogenation of phenolic benzyl ether, Cbz, benzyl ester, nitro and olefin functions distinguishing from the MPM (4-methoxybenzyl) protective group for the phenolic hydroxy groups was accomplished by the addition of pyridine to the Pd/C-catalyzed reduction system.