84268-56-4

Upstream product

• 87265-43-8 N-(3-benzyloxy-4-methoxybenzyl)-2-aminoethanol 
• 836-42-0 4-benzyloxybenzyl chloride 
• 84293-24-3 N-(3-benzyloxy-4-methoxybenzyl)-N-(2-bromoethyl)-4-benzyloxybenzylamine 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 81782-24-3 N-(3-benzyloxy-4-methoxybenzyl)aziridine 
• 1699-38-3 3-benzyloxy-4-methoxy-benzyl chloride 

Downstream Products

• 15778-82-2 N-(4'-benzyloxybenzyl)-7-benzyloxy-6-methoxytetrahydroisoquinoline 
• 84268-57-5 N-(3-benzyloxy-4-methoxybenzyl)-N-(4-benzyloxybenzyl)aminoacetaldehyde 
• 15778-86-6 (+/-)-corgoine 

Relevant academic research and scientific papers

A NOVEL ROUTE TO THE SYNTHESIS OF SUBSTITUTED N-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES. SYNTHESIS OF SENDAVERINE AND CORGOINE

The condensation product of 2-aminoethanol with substituted benzaldehyde was reduced and N-benzylated with substituted benzyl chloride followed by PPA cyclization to obtain substituted N-benzyl-tetrahydroisoquinolines; likewise the condensation product of

A Novel Synthesis of the 2-Benzylisoquinoline Alkaloids, Sendaverine and Corgoine, with Aziridinium Salts as Reactive Intermediates

A total synthesis of the 2-benzylisoquinoline alkaloids sendaverine (1) and corgoine (2) has been achieved by employing the ring-opening reaction of aziridinium salts as a key step.