84268-81-5

Upstream product

• 84268-84-8 1-benzyl-2-cyano-6-methyl-piperidine 
• 84268-80-4 (2R,6S)-1-Benzyl-6-methyl-2-propyl-piperidine-2-carbonitrile 
• 84268-83-7 1-Benzyl-2-cyano-6-methyl-3-piperideine 
• 642092-06-6 Toluene-4-sulfonic acid (Z)-1-methyl-4-trimethylsilanyl-but-3-enyl ester 
• 616899-92-4 N-benzyl-N-(Z)-(1-methyl-4-trimethylsilylbut-3-enyl)amine 
• 158070-10-1 (+/-)-(Z)-5-trimethylsilylpent-4-en-2-ol 
• 2117-13-7 5-(trimethylsilyl)-4-pentyn-2-ol 
• 89873-74-5 (+/-)-trans-1-benzyl-2-methyl-6-propyl-1,2,3,6-tetrahydropyridine 

Relevant academic research and scientific papers

Rapid access to trans-2,6-disubstituted piperidines: Expedient total syntheses of (-)-solenopsin A and (+)-epi-dihydropinidine

Expedient syntheses of (-)-solenopsin A and (+)-epi-dihydropinidine are reported, the key step in both being the one-pot multicomponent aza-silyl-Prins condensation reaction to yield a trans dihydropyridine. Georg Thieme Verlag Stuttgart.

2-CYANO Δ3 PIPERIDINES VI: A GENERAL METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CIS AND TRANS 2,6-DIALKYLPIPERIDINE ALKALOIDS

The cis 2,6-dialkylpiperidine alkaloid (+/-) dihydro-pinidine 7b and the trans alkaloid (+/-) solenopsin A 5a were synthesized from a common α-aminonitrile synthon 1.The key step in this synthesis was the stereoselective reductive decyanation of the 1-benzyl-2-cyano-2',6-dialkylpiperidines 3a and 3b.