84270-05-3

Upstream product

• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 63139-21-9 4-ethylphenylboronic acid 
• 100-63-0 phenylhydrazine 
• 842116-58-9 C₁₅H₁₄BrNO 
• 16331-45-6 p-ethylbenzoyl chloride 
• 18220-90-1 4-ethylbenzophenone 
• 112410-23-8 tebufenozide 
• 2301-17-9 4-ethyl-benzophenone-seqtrans-oxime 

Downstream Products

• 37135-35-6 2-(4-ethylphenyl)-1,3-benzoxazole 

Relevant academic research and scientific papers

Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source

In present work, we have explored a Cu(acac)2/vasicine-catalyzed regioselective hydrodehalogenation methodology of o-haloanilides using EtOH as hydrogen source and solvent. The catalytic system could selectively dehalogenate 2-Br and 2-I, and features regioselective, efficient and functional group tolerance.

Efficient Pd-Catalyzed Hydrodehalogenation of o -Haloanilides in Water

In the present work, we have developed a practical methodology for the hydrodehalogenation of o -haloanilides using PdCl 2at 100 °C under mild conditions in water. The catalytic system could selectively dehalogenate both aryl chloride and aryl bromide and exhibit a broad functional group tolerance.

Synthesis of Secondary Amides through the Palladium(II)-Catalyzed Aminocarbonylation of Arylboronic Acids with Amines or Hydrazines and Carbon Dioxide

A new Pd-catalyzed aminocarbonylation of arylboronic acids with amines or phenylhydrazines has been developed. Various secondary amides were produced from readily available substrates and cheap common metal catalysts in a CO atmosphere (balloon). Remarkably, we presents the first example of aminocarbonylations between arylboronic acids and phenylhydrazines.

N-aryl secondary aryl amide synthetic method

The invention discloses an N-aryl secondary aryl amide synthetic method. The synthetic method is characterized in that arylboronic acid and aromatic primary amine, and a main catalyst and a cocatalystare added in a solvent, then the components are subjected to a carbonylation reaction and then separation and purification to obtain the N-aryl secondary aryl amide, and CO is introduced into a reaction system during a reaction process so that the pressure of the reaction system is 0.1-5 MPa. The synthetic method is concise and efficient, aromatic amine and organic boric acid and CO which are stable in air and easily available can be taken as the reaction raw materials, under existence of the solvent, the catalysts are added, and the secondary aryl amide is synthesized with high efficiency under mild reaction condition.

New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group

We have designed cancer antiproliferative compounds, starting from aniline or phenol derivative, which comprise one or two nitrooxymethylphenyl groups as do the hybrid drugs NCX4040 and NCX530. Compound 2a with p- nitrooxymethylbenzoyl-oxy and -amino grou

A novel convenient synthesis of 1,3,4-oxadiazol-2-ones and -thiones from N-tert-butyldiacylhydrazines

An attractive, novel, convenient process for the preparation of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones from the reaction of various equivalent and non-equivalent N-tertbutyldiacylhydrazines with potassium tert-butoxide followed by treatment with phosgene or thiophosgene, respectively, has been discovered. The 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones are confirmed both analytically and chemically. Various equivalent and non-equivalent N-tert-butyldiacylhydrazines are conveniently synthesized from the reaction of tert-butylhydrazine hydrochloride in the presence of i-Pr2NEt, with acid chloride #1 followed by subsequent treatment with acid chloride #2. Both the syntheses of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones, as well as N-tert-butyldiacylhydrazines, are easily performed on multigram scales.