84275-18-3Relevant academic research and scientific papers
Transesterification of the α-keto ester in methyl pheophorbide-a
Shinoda, Satoshi,Osuka, Atsuhiro
, p. 4945 - 4948 (1996)
Transesterification of the α-keto methyl ester in methyl pheophorbide- a proceeds smoothly under neutral conditions, allowing the preparation of a variety of models such as steroid-pheophorbide, pyromellitimide-pheophorbide, thymidine-pheophorbide, pheoph
METHOD OF PREPARING PURPURIN 18 FROM LIVE CHLORELLA
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Page/Page column 7; 9, (2016/11/21)
The present invention relates to a method for preparing purpurin 18 which is a photosensitizer (PS) useful for photodynamic therapy (PDT) and, more specifically, to a method for preparing purpurin 18, which comprises steps of: extracting chlorophyll alpha by using intact chlorella cells itself which is not broken; and obtaining a precursor material of purpurin 18 and methyl or ethyl pheophorbides from the extracts. According to the present invention, it is possible to produce purpurin 18 with at a high yield through a relatively simple process.(AA) Purpurin18 manufacturing process1(BB) Chlorella(CC) Chlorophyll a/li>(DD) Methyl pheophorbide a/li>(EE) Purpurin 18(FF) Purpurin 18 precursorCOPYRIGHT KIPO 2016
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.
Wongsinkongman, Prapai,Brossi, Arnold,Wang, Hui-Kang,Bastow, Kenneth F,Lee, Kuo-Hsiung
, p. 583 - 591 (2007/10/03)
A methanolic crude extract of the plant Garuga pinnata Roxb. (Burseraceae) showed promising cytotoxic activity against a panel of human tumor cell lines in vitro, including KB and its drug-resistant sublines (Ferguson et al. Cancer Res. 1988, 48, 5956). Pheophorbide-a and-b methyl esters (3,4) were isolated as active principles with broad photo-dependent cytotoxic activities in the micromolar range. These findings prompted SAR studies of known and novel pheophorbide-a derivatives as photo-dependent and photo-independent cytotoxic agents. The results showed that zinc-protoporphyrin IX (10), zinc 13(R)-hydroxypheophorbide-a methyl ester (22), and zinc chlorin-e6 trimethyl ester (13) possessed photo-independent cytotoxic activity. Compounds 13 and 22 were the most active cytotoxic agents of the series (mean ED(50) 4.6 +/- 1.0 microM and 5.7 +/- 0.7 microM, respectively) against KB cells incubated in the dark.
