84288-96-0Relevant academic research and scientific papers
Clean catalytic oxidation of 8-hydroxyquinoline to quinoline-5,8-dione with tBuOOH in the presence of covalently bound FePcS-SiO2 catalysts
Zalomaeva, Olga V.,Sorokin, Alexander B.,Kholdeeva, Oxana A.
, p. 1076 - 1082 (2010)
The clean catalytic oxidation of 8-hydroxyquinoline (8-HQ) with tert-butyl hydroperoxide to quinoline-5,8-dione (QD), a molecular framework fragment of antitumor compounds, over silica-supported iron tetrasulfophthalocyanine catalysts (FePcS) is reported. The pronounced influence of the FePcS state (monomer vs. dimer) and the support (amorphous SiO2vs. mesoporous MCM-41) on the catalytic activity and selectivity is revealed. Depending on the catalyst structure, turnover frequency values determined from the initial rates of 8-HQ consumption varied from 215 to 3570 h-1.The effects of solvent, temperature, reagent concentrations and catalyst amounts on the substrate conversion and QD selectivity were studied to optimize the reaction conditions. With an optimal catalyst, the yield of the target product reached 66%. The truly heterogeneous nature of the catalysis was also demonstrated.
