84327-84-4Relevant academic research and scientific papers
Derivative containing 1,3,4-oxdiazole sulfenyl acetamide, preparation method and application thereof
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Paragraph 0018; 0029, (2016/12/26)
The invention discloses a derivative containing 1,3,4-oxdiazole sulfenyl acetamide, and a preparation method and application thereof. The derivative has a general structure as follows, wherein R1 represents substituted aromatic hydrocarbon, and substituted benzyl, and R2 represents substituted aromatic hydrocarbon. The derivative has good plant bacteria and plant virus resistance activity and good stability, and can be used for anti-bacteria and anti-viral medicaments and drugs.
Antiviral and Antibacterial Activities of N-(4-Substituted phenyl) Acetamide Derivatives Bearing 1,3,4-Oxadiazole Moiety
Chen, Ling,Wang, Peiyi,Li, Zhenxing,Zhou, Lei,Wu, Zhibing,Song, Baoan,Yang, Song
, p. 1236 - 1244 (2016/12/27)
In this paper, a series of N-(4-substituted phenyl) acetamide derivatives bearing 1,3,4-oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus (TMV) but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri. Among the derivatives, TC8and TC20exerted the strongest curative activities against TMV, with half-maximal effective concentration (EC50) values of 239.5 and 236.2 μg/mL, respectively, which were comparable to that of ningnanmycin (EC50=273.2 μg/mL). Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.
N-substituted derivatives of 5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl-2- sulfanyl acetamide as valuable bioactive compounds
Rehman, Aziz-Ur,Gul, Samreen,Abbasi, Muhammad Athar,Nafeesa, Khadija,Siddiqa, Asia,Khan, Khalid Mohammed,Shahid, Muhammad,Subhani, Zinayyera
, p. 503 - 511 (2014/08/05)
In the described research work, a new series of N-substituted derivatives of 5-(4- chlorophenyl)-1,3,4-Oxadiazol-2-yl-2-sulfanyl acetamide has been synthesized. The synthesis was carried out by converting 4-chlorobenzoic acid (1) into ethyl 4-chlorobenzoate (2), 4- chlorobenzohydrazide (3) and then 5-(4-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) respectively. The target molecules 6a-o were synthesized by reacting compound 4 with different N-alkyl/aryl substituted 2-bromoacetamide (5a-o) in equimolar ratios of using DMF and sodium hydride (NaH). The structure of all the synthesized compounds was confirmed by spectral data like EI-MS, IR and 1H-NMR. The compounds were also analysed for antimicrobial & hemolytic activity and most of them were found active against the selected microbial species at variable extent relative to reference standards. But 6f and 6o were the active against the selected panel of microbes and former was most potent one. This series revealed less toxicity and may consider for further biological screening and application trial except 6g and 6j, exhibiting high cytotoxicity.
