84332-06-9

Usage

InChI:InChI=1/C7H8N2O3S/c1-12-5-4(6(10)11)3-8-7(9-5)13-2/h3H,1-2H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 100426-81-1 2-(methylthio)-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 15400-57-4 methyl 4-methoxy-2-(methylthio)pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis method and application of isoxazole pyrimidine derivative

The invention relates to the technical field of organic molecule synthesis, and provides a synthesis method of an isoxazole pyrimidine derivative, in the synthesis method, firstly, 4-(A2)-2-(A1)-pyrimidine-5-carboxylic acid is provided as a raw material, and is sequentially subjected to an amide condensation reaction, a substitution reaction and a substitution cyclization reaction with different reactants, and through three simple reaction processes, the isoxazole pyrimidine derivative is finally obtained. In the reaction process, the reactants in each step are compounds conventionally available in the field, continuous reaction with 4-(A2)-2-(A1)-pyrimidine-5-carboxylic acid as a raw material is realized, the reaction time is shortened, the reaction efficiency is improved, large instruments and equipment do not need to be provided in the reaction process, and harsh reaction conditions are not need, and the method is convenient, simple, safe and reliable, is beneficial to large-scale preparation, and is suitable for industrial popularization and application.

Diarylpyrimidine dipyridone derivative as well as preparation method and application thereof (by machine translation)

The invention provides a diarylpyrimidine dipyridone derivative, which has the structure shown in the general formula I shown below. The invention also relates to a preparation method of the derivative and application of the derivative as HIV inhibitor in preparation of anti-AIDS drugs. (by machine translation)

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

A series of pyrido[2,3-d]pyrimidin-5-ones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). FMS inhibitors may be useful in treating rheumatoid arthritis and other chronic infla