84346-53-2

Usage

Uses

Used in Pharmaceutical Industry:
Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin is used as a drug delivery system for improving the solubility and bioavailability of poorly soluble drugs. Its hydrophobic cavity can encapsulate guest molecules, facilitating their transport and absorption in the body.
Used in Food Industry:
Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin is used to improve the stability and flavor of certain food ingredients. Its ability to encapsulate guest molecules helps protect sensitive ingredients from degradation and enhance their flavor profile.
Used in Cosmetics Industry:
Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin is used in cosmetics to improve the stability and effectiveness of active ingredients. Its encapsulation properties can protect sensitive ingredients from environmental factors and enhance their delivery to the skin.
Used as a Chiral Selector in Chromatography:
Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin is used as a chiral selector for enantioseparation in chromatography. Its unique structure allows for the selective interaction with enantiomers, enabling their separation and analysis in various applications.

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 7585-39-9 β‐cyclodextrin 

Relevant academic research and scientific papers

Migration of secondary tert-butyldimethylsilyl groups in cyclomalto-heptaose and -octaose derivatives

When 2,6-di-O-tert-butyldimethylsilylated cyclomalto-oligosaccharides (cyclodextrins) are treated with allyl or methyl iodide and NaH in dry tetrahydrofuran, O-2 → O-3 migration of the secondary 2-O-tert-butyldimethylsilyl groups occurs, leading to 2-O-alk(en)yl-3,6-di-O-tert-butyldimethylsilyl-cyclodextrin derivatives. The detection and identification of the reaction step during which migration occurred is described and possible mechanisms of migration are discussed.

Effective syntheses of per-2,3-di- and per-3-O-chloroacetyl-β-cyclodextrins: A new kind of ATRP initiators for star polymers

Selective chloroacetylations at per-2,3- and per-3-positions of β-cyclodextrin have been achieved via protection-deprotection methods. The reaction condition of pH >4 controlled by appropriate proton scavenger is essential for obtaining designed chloroacetylation degree under effective protection, as well as for high yield with less side-products. The β-cyclodextrin derivatives with 14 or 7 chloroacetyl groups are useful initiators for synthesizing star polymers with well-defined structure by atom transfer radical polymerization.

Binding and catalytic properties of 2-0-and 3-o-permethylated cyclodextrins

Hexakis(3-0-methyl)-α,-cyclodextrin (3α) bound tom-and p-nitrophenolate ions more strongly, whereas hexakis(2-0-methy1)-α- cyclodextrin (2α) bound less strongly than native α-cyclodextrin. ROESY spectra showed that the 3-0-mefhyl groups of 3a interact with the guest protons, whereas 2-0-methyl groups of 2a do not. 3a accelerated and 2a decelerated the cleavage of m-nitrophenyl acetate in an alkaline solution, suggesting that the C(2)-OH of α-cyclodextrin is more catalytic than the C(3)-OH. However, the catalytic effect of 3a was much smaller than that of native a-cyclodextrin. Loss of hydrogen bonding between the C(3)-OH and C(2)-OH by 3-O-permethylation is responsible for the small catalytic effects of 3α. Similar results were obtained for β-cyclodextrin analogs.