Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin

Base Information

• Chemical Name: Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin
• CAS No.: 84346-53-2
• Molecular Formula: C126H266 O35 Si14
• Molecular Weight: 2734.64
• Mol file: 84346-53-2.mol

Synonyms:2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane,b-cyclodextrin deriv.;Heptakis(2,6-di(tert-butyldimethylsilyl))-b-cyclodextrin;Heptakis(2,6-di-O-tert-butyldimethylsilyl) cyclomaltoheptaose;Heptakis(2,6-di-O-tert-butyldimethylsilyl)-b-cyclodextrin

Chemical Property of Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin

Chemical Property:

• Melting Point: 289-291 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
• Boiling Point: 1456.9±65.0 °C(Predicted)
• PKA: 11.62±0.70(Predicted)
• PSA: 400.05000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 27.18240

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin

There total 1 articles about Heptakis-(2,6-di-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyldimethylsilyl chloride (18162-48-6) + β‐cyclodextrin (7585-39-9) → heptakis(2,6-di-O-tert-butyldimethylsilyl)cyclomaltoheptaose (84346-53-2)

Guidance literature:

With pyridine; dmap; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1021/jo00117a049

Reference yield: 78.0%

benzyl bromide (100-39-0) + heptakis(2,6-di-O-tert-butyldimethylsilyl)cyclomaltoheptaose (84346-53-2) → Heptakis(2-O-benzyl-3,6-di-O-tert-butyldimethylsilyl)-β-cyclodextrin

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) r.t., 30 min, 2.) reflux, 19 h;

DOI:10.1021/jo00117a049

upstream raw materials:

tert-butyldimethylsilyl chloride

β‐cyclodextrin