84356-30-9Relevant academic research and scientific papers
Microwave-assisted synthesis of alkyl thiocyanates
Bound, D. James,Bettadaiah,Srinivas
, p. 1138 - 1144 (2013/03/28)
Microwave irradiation accelerated the reaction of t-alkyl, allyl, and benzyl halides with Zn(SCN)2 to afford thiocyanates in excellent yields and high selectivity with the formation of isothiocyanates only in minor proportions. Because thiocyanates are stable intermediates to thiols, the method also affords facile access to corresponding thiols.
Ultrasound-assisted nucleophilic substitution reaction of t-Alkyl halides with zinc and titanium thiocyanate
Bettadaiah,Gurudutt,Srinivas
, p. 2293 - 2299 (2007/10/03)
Ultrasound promotes nucleophilic substitution of t-alkyl halides with ambident thiocyanate nucleophile, in the form of its zinc or titanium thiocyanate, under mild conditions to afford the corresponding thiocyanates selectively, in good to excellent yields. This improved synthetic methodology affords a facile access to tertiary thiols via the corresponding thiocyanate intermediates.
Nucleophilic Substitution Reactions of Alkyl Halides By Using New Polymer-Supported Reagents Containing Hemin
Saito, Kiyoshi,Harada, Kaoru
, p. 2562 - 2566 (2007/10/02)
A new polymer reagent consisting of hemin, divinylbenzene, and 2-methyl-5-vinylpyridine was synthesized by suspension copolymerization.Substitution reactions of primary, secondary, and tertiary alkyl halides with the hemin copolymer combined with cyanide, azide, and thiocyanate ions were given satisfactory yields.This reaction mechanism was revealed to be a SNi type on the basis of stereochemical study.The hemin copolymer was not only a polymer-supported reagent with functional capabilities, but also served to separate the product from the reaction mixture.
