843608-15-1

Basic information

• Product Name: N-(2-AMINO-6-METHYL-4-PYRIMIDINYL)-N-(4-FLUOROPHENYL)AMINE
• Synonyms: N4-(4-FLUOROPHENYL)-6-METHYL-2,4-PYRIMIDINEDIAMINE;N-(2-AMINO-6-METHYL-4-PYRIMIDINYL)-N-(4-FLUOROPHENYL)AMINE
• CAS NO: 843608-15-1
• Molecular Formula: C11H11FN4
• Molecular Weight: 218.23
• Mol File: 843608-15-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-AMINO-6-METHYL-4-PYRIMIDINYL)-N-(4-FLUOROPHENYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINO-6-METHYL-4-PYRIMIDINYL)-N-(4-FLUOROPHENYL)AMINE(843608-15-1)
• EPA Substance Registry System: N-(2-AMINO-6-METHYL-4-PYRIMIDINYL)-N-(4-FLUOROPHENYL)AMINE(843608-15-1)

Safety Data

• Hazardous Substances Data: 843608-15-1(Hazardous Substances Data)

Upstream product

• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors

Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here we have reported structure-based design, synthesis and biological evaluation of 2,4-diaminopyrimidine derivatives (6a-6w) as potential caspase-1 inhibitors. Six compounds 6m, 6n, 6o, 6p, 6q and 6r showed significant enzymatic inhibition with IC5 0 ranging from 0.022 to 0.078 μM. These compounds also displayed excellent cellular potency at sub-micromolar concentration. Moreover, molecular docking studies provided the useful binding insights specific for caspase-1 inhibition. All these results indicated that compounds 6m, 6n and 6o could be potential leads for the development of newer caspase-1 inhibitors as anti-inflammatory agents.