843662-52-2Relevant academic research and scientific papers
An efficient and practical sequential one-pot synthesis of suprofen, ketoprofen and other 2-arylpropionic acids
Neumann, Helfried,Brennfuehrer, Anne,Beller, Matthias
experimental part, p. 2437 - 2442 (2009/10/06)
A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.
CHEMICAL COMPOUNDS
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Page/Page column 126, (2008/06/13)
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
