843666-40-0

Basic information

• Product Name: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER
• Synonyms: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER;18-(tert-Butoxy)-18-oxooctadecanoic acid;18-(tert-Butoxy)-18-oxostearic acid, tert-Butyl 17-carboxyheptadecanoate;18-(tert-Butoxy);-18-oxooctadecanoic acid;Octadecanedioic acid,1-(1,1-dimethylethyl) ester;18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid;Octadecanedioic acid mono(1,1-dimethylethyl) ester
• CAS NO: 843666-40-0
• Molecular Formula: C₂₂H₄₂O₄
• Molecular Weight: 370.58
• Mol File: 843666-40-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 68 °C
• Boiling Point: 470.7±18.0 °C(Predicted)
• Appearance: /
• Density: 0.950±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER(843666-40-0)
• EPA Substance Registry System: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER(843666-40-0)

Safety Data

• Hazardous Substances Data: 843666-40-0(Hazardous Substances Data)

Usage

Uses

18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.

Upstream product

• 871-70-5 octadecanedioic acid 
• 45270-18-6 1,18-octadecanedioyl dichloride 
• 505-54-4 thapsic acid 
• 75-65-0 tert-butyl alcohol 
• 821-38-5 1,14-tetradecanedioic acid 
• 41059-02-3 9-bromononanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 843666-34-2 octadecanedioic acid tert-butyl ester-2,5-dioxopyrrolidin-1-yl ester 
• 1448547-34-9 (S)-1-(aminooxy)-19-carboxy-2,7,16,21-tetraoxo-9,12-dioxa-3,6,15,20-tetraazaoctatriacontan-38-oic acid 
• 1118767-15-9 17-(4-(S)-1-tert-butoxycarbonyl-3-{2-[2-({2-[2-(2,5-dioxopyrrolidin-1-yloxycarbonylmethoxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]ethylcarbamoyl}propylcarbamoyl)heptadecanoic acid tert-butyl ester 

Relevant articles and documents

Preparation method of long-chain aliphatic dicarboxylic acid mono-tert-butyl ester

The invention provides a method for obtaining the long-chain aliphatic dicarboxylic acid mono-tert-butyl ester through monohydrolysis of the long-chain aliphatic dicarboxylic acid di-tert-butyl ester by controlling the reaction conditions of monohydrolysis; and the raw material cost is low, the yield is high, the post-treatment method is simple, and the method is suitable for industrial production.

Preparation method of long-chain alkyl diacid mono-tert-butyl ester

The invention relates to a preparation method of long-chain alkyl diacid mono-tert-butyl ester, belonging to the technical field of organic synthesis. According to the invention, long-chain alkyl diacid is used as an initial raw material and reacts with oxalyl chloride to generate long-chain monoacyl chloride, and the long-chain monoacyl chloride and tert-butyl alcohol are subjected to an esterification reaction to generate the long-chain alkyl diacid mono-tert-butyl ester. According to the invention, a novel synthesis route is adopted, and raw material cost is reduced; and the method has the characteristics of mild reaction conditions, simple process operation, high product purity, high production efficiency and the like, and has good application prospects.

Preparation method of octadecanedioic acid mont-butyl - PFP

The invention discloses a preparation method of octadecanedioic acid mont-butyl - PFP, which comprises the preparation of compound 1 and preparation of octadecanedioic acid mont-butyl - PFP. The preparation method of the octadecanedioic acid monoester - PFP comprises the following steps: A1, adding compound 1, pyridine, DMF, opening stirring, completely dissolving, dropwise adding trifluoroacetic acid pentafluorophenol ester, precipitating solid and re-reacting in the reaction kettle. A2. The prepared compound DMF is simple in reaction and post-treatment, is simple in reaction and post-treatment, can be directly used for preparing the octadecanedioic acid mont-butyl 1.4 kg - PFP, and can be directly used for preparing - PFP tert-butyl octadecanedioic acid mont-butyl acid or octadecanedioic acid tert-butyl ester - PFP. 1. The method is simple in reaction and post-processing.