84375-17-7

Upstream product

• 84375-15-5 1-(3-hydroxybenzyl)-6-methoxy-3,4-dihydroisoquinoline 
• 95712-62-2 1-(3-Benzyloxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 95712-64-4 2-<(1-Phenyl-1H-tetrazol-5-yl)oxy>-N-formylmorphinan-6-one 
• 95712-63-3 (+/-)-2-<(1-phenyl-1H-tetrazol-5-yl)oxy> morphinan-6-one 
• 84415-71-4 (+/-)-N-formyl-1-(3-hydroxybenzyl)-6-methoxy-1,2,3,4,5,8-hexahydroisoquinoline 

Relevant academic research and scientific papers

A convenient synthesis of Δ7,8-Morphinan-6-one and its direct oxidation to 14-hydroxy-Δ7,8-morphinan-6-one

Synthesis of Δ7,8-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel.

Synthesis of (-)- and (+)-2-hydroxy-6-keto-N-methylmorphinans, their O-methyl ethers, and 2-deoxy congeners

Bischler-Napieralski cyclization of the known phenylacetamide 1, followed by selective ether cleavage of the 3,4-dihydroisoquinoline 2 and sodium borohydride reduction, afforded the tetrahydroisoquinoline 4.Optical resolution of 4 with tartaric acid gave