95712-63-3

Upstream product

• 84375-11-1 (+/-)-N-formyl-2-hydroxymorphinan-6-one 
• 84375-17-7 (+/-)-1-(3-hydroxybenzyl)-6-methoxy-1,2,3,4,5,8-hexahydroisoquinoline 
• 84415-71-4 (+/-)-N-formyl-1-(3-hydroxybenzyl)-6-methoxy-1,2,3,4,5,8-hexahydroisoquinoline 
• 14210-25-4 5-Chloro-1-phenyltetrazole 
• 95712-64-4 2-<(1-Phenyl-1H-tetrazol-5-yl)oxy>-N-formylmorphinan-6-one 

Downstream Products

• 128935-36-4 (+/-)-N-phenethylmorphinan-6-one 
• 81451-66-3 (+/-)-ketomorphinan 
• 128935-39-7 (+/-)-2-<(1-phenyl-1H-tetrazol-5-yl)oxy>-N-acyl morphinan-6-one 
• 84395-20-0 2-<(1-Phenyl-1H-tetrazol-5-yl)oxy>-N-methylmorphinan-6-one 

Relevant academic research and scientific papers

A convenient synthesis of Δ7,8-Morphinan-6-one and its direct oxidation to 14-hydroxy-Δ7,8-morphinan-6-one

Synthesis of Δ7,8-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel.

Synthesis of (+/-)-2-Hydroxy-N-methylmorphinan-6-one and (+/-)-N-Methylmorphinan-6-one

The synthesis of (+/-)-2-hydroxy-N-methylmorphinan-6-one (II) and (+/-)-N-methylmorphinan-6-one (I) is reported.