84376-25-0

Upstream product

• 118-55-8 phenyl Salicylate 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 108-95-2 phenol 

Downstream Products

• 783371-16-4 5-fluoro-2-hydroxy-N-(6-methyl-pyridin-2-yl)-benzamide 
• 783371-15-3 5-fluoro-2-hydroxy-N-(5-methyl-pyridin-2-yl)-benzamide 
• 783371-14-2 5-fluoro-2-hydroxy-N-(4-methyl-pyridin-2-yl)-benzamide 
• 783371-17-5 5-fluoro-2-hydroxy-N-(3-hydroxy-pyridin-2-yl)-benzamide 
• 1334312-06-9 C₁₃H₁₁FN₂O₂ 
• 1334312-07-0 C₁₃H₁₁FN₂O₂ 

Relevant academic research and scientific papers

DIRECT FLUORINATION OF ARYL OXYGEN COMPOUNDS

A study has been made of the reaction of aryl oxygen compounds with elemental fluorine in hydrogen fluoride and acetonitrile.Hydrogen fluoride acted as a good solvent in the reaction of salicylic acid, salicylaldehyde and phenyl salicylate.Salicylalcohol

Nickel-catalyzed CO/OH annulation of salicylate esters with alkynes: Activation of CO bond in Esters

The Ni-catalyzed CO/OH annulation of salicylate esters with alkynes, leading to the production of chromone derivatives is reported. The key step in the reaction is the cleavage of an acyl CO bond. The presence of a base is essential for the reaction to proceed.

A new group of potential antituberculotics: N-(2-pyridylmethyl) salicylamides and N-(3-pyridylmethyl)salicylamides

As a part of our systematic study of antimycobacterially active derivatives of salicylamides, a series of nineteen derivatives of N-(2-pyridylmethyl) salicylamides and N-(3-pyridylmethyl)salicylamides was synthesised. The compounds exhibited in vitro activity against Mycobacterium tuberculosis and M. avium. Their lipophilicity, RM, was measured by thin layer chromatography on silica gel impregnated with trioctadecylsilane and the logarithm of the partition coefficient (octanol-water), logP, was calculated. Both the parameters of lipophilicity correlated. The quantitative relationship between the structure and antimycobacterial activity was calculated. Antimycobacterial activity increased with an increase in lipophilicity. The N-(2-pyridylmethyl)salicylamide derivatives were more active than the derivatives of isomeric N-(3-pyridylmethyl)salicylamides. The geometry of compounds was calculated and the calculation was verified by measuring the length of the hydrogen bond between hydroxyl and carbonyl groups on the salicylic moiety.