84379-34-0

Usage

Uses

Used in Organic Synthesis:
2-(Benzyloxy)-1,3-dibromo-5-methylbenzene is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new and effective compounds for medical and agricultural applications.
Used as a Reagent in Chemical Reactions:
2-(Benzyloxy)-1,3-dibroMo-5-Methylbenzene serves as a reagent in various chemical reactions, facilitating the formation of desired products and aiding in the advancement of chemical research and development.
Used as a Precursor for Synthesis of Other Organic Compounds:
2-(Benzyloxy)-1,3-dibromo-5-methylbenzene is employed as a precursor in the synthesis of other organic compounds, expanding its utility in the creation of a diverse range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Benzyloxy)-1,3-dibromo-5-methylbenzene is used as a key intermediate for the production of specific drugs, playing a crucial role in the development of novel therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2-(Benzyloxy)-1,3-dibroMo-5-Methylbenzene is used as an intermediate for the synthesis of various agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.
Safety Considerations:
It is important to handle 2-(Benzyloxy)-1,3-dibromo-5-methylbenzene with care, as it may pose health hazards if not properly managed or stored. Adequate safety measures should be taken to minimize risks during its use in various applications.

Upstream product

• 2432-14-6 3,5-dibromo-4-hydroxytoluene 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 84379-35-1 1-(phenylmethoxy)-2,6-dicarboxy-4-methylbenzene 
• 84379-36-2 2,6-bis<3-(3-bromopropyl)ureido>-4-methylbenzene 
• 84379-42-0 1-(phenylmethoxy)-2,6-bis(hexahydro-2-oxopyrimidinyl)-4-methylbenzene 
• 84379-23-7 35,37-dioxo-34,38-dimethoxy-33,36-bis(phenylmethoxy)-4,15,26,31-tetramethyl-8,12,18,22-tetraazaheptacyclo<27.3.1.1^2,6.1^8,12.1^13,17.1^18,22.1^24,28>octaconta-1(33),2(34),3,5,13(36),14,16,24(38),25,27,29,31,-dodecaene 
• 620988-42-3 2-bromo-4-methyl-6-(2-hydroxyphenyl) phenol benzyl ether 

Relevant academic research and scientific papers

Fourth subgroup metal complex with rigid annular bridging structure and application of fourth subgroup metal complex

The invention belongs to the technical field of olefin polymerization catalysts, and particularly relates to a fourth subgroup metal complex with a rigid annular bridging structure and an application of the fourth subgroup metal complex. The fourth subgroup metal complex provided by the invention has a structure represented by a formula (A) or a formula (B), X is halogen or alkyl; and M is titanium, zirconium or hafnium. On the basis of a non-metallocene catalyst, a bridging structure in catalyst molecules is improved and upgraded, and a brand-new metal complex with excellent catalytic performance and good high-temperature tolerance is designed; when the fourth subgroup metal complex is used as a main catalyst to catalyze olefin polymerization reaction, under the activation action of a small amount of mixed cocatalyst, the fourth subgroup metal complex can efficiently catalyze the copolymerization reaction of ethylene and alpha-olefin to obtain polyolefin with high molecular weight and high comonomer insertion rate.

Host-Guest Complexation. 32. Spherands Composed of Cyclic Urea and Anisyl Units

Five new spherands and three new hemispherands containing cyclic urea units have been designed and synthesized, and their binding properties have been examined.Formally, these macrocycles are composed by attaching to one another the following units: 2,6-disubstituted anisyl, or A; 2,6-disubstituted 4-methylanisyl, or A'; N,N-disubstituted tetrahydro-2-pyrimidinone, or U; 2,6-disubstituted 1-(allyloxy)-4-methylbenzene, or A'a; 2,6-disubstituted 1-(benzyloxy)-4-methylbenzene, or A'b; 2,6-disubstituted 4-methylphenol, or A'h; 1,2-disubstituted benzene, or B; and CH2 groups.Host structures and key intermediates are visualized by line formulas in which adjacent letters indicate bonded units. The macroring acts as a semirigid support structure for convergently arranged carbonyl and methoxy groups.Key ring-closing reactions involve urea NH group substitution of ArCH2Br in (CH2)4O-NaH under high dilution.Treatment of U(A'UH)2 with (BrCH2)2B gave U(A'UCH2)2B (1, 7percent), of A(AUH)2 with (BrCH2)2B gave A(AUCH2)2B (2, 11percent), of A(AUH)2 with (BrCH2)2A' gave A(AUCH2)2A' (3, 32percent) of A'b(A'UH)2 with (BrCH2)2A'a gave A'b(A'UCH2)2A'a (4, 41percent), deallylation of which with Pd-EtOH-TsOH gave A'b(A'UCH2)2A'h (5, 25percent), of U(A'CH2Br)2 with (HU)2A' gave U(A'CH2U)2A' (6, 60percent), and of A'b(A'CH2Br)2 with (HU2)A'b gave A'b(A'CH2U)2A'b (7, 41percent), which was hydrolytically debenzylated to give A'h(A'CH2U)2A'h (43percent), methylation of which produced A'(A'CH2U)2A' (8, 71percent).These compounds were generally purified as their NaBr complexes, which were decomplexed by crystallizing the free host from MeOH-H2O mixtures by MeOH evaporation (a phase-transfer process).Crystal structures of complexes A(AUCH2)2A'*NaBr*H2O (3*NaBr*H2O) and A(AUCH2)2A'*CsClO4*H2O (3*CsClO4*H2O) are discussed.Association constants (Ka) between host and guest to give complexes were determined by extracting picrate salts (guests) from D2O into CDCl3 in the absence and presence of hosts at 25 deg C.The rates of extraction were essentially instantaneous on the human time scale.The free energies for complexation for the seven hosts with picrate salts of Li+, Na+, K+, Rb+, Cs+, NH4+, CH3NH3+, and t-BuNH3+ were determined.These -ΔG0 values (kcal mol-1) ranged from a high of ca. 18.3 (U(A'UCH2)2B (1)) for Li+ to a low 7.2 (U(A'CH2U)2A' (6)) for (CH3)3CNH3+.Interesting structural recognition factors (KaG/KaG') for a host distinguishing between two similar guests (G and G') are as follows: Li+/Na+, U(A'UCH2)2B (1), 30; Na+/Li+, A'b(A'CH2U)2A'b (7), 3400; Na+/K+, A(AUCH2)2B (2), 2300; K+/Na+, A(AUCH2)2A' (3), 3; K+/Rb+, A'b(A'UCH2)2A'a (4), 110; Rb+/Cs+, A'b(A'UCH2)2A'a (4), 25; Cs+/Rb+, U(A'UCH2)2B (1), 2; NH4+/CH3NH3+, A(AUCH2)2A' (3), 9; CH3NH3+/NH4+, U(A'UCH2)2B (1), 1.7; CH3NH3+/t-BuNH3+, A'b(A'UCH2)2A'a (4), 4600; t-BuNH3+/CH3NH3+, U(A'UCH2)2B (1), 6.Correlations between the structures of hosts and guests and their free energies of binding are interpreted interms of the principles of complementarity and of preorganiz...

Strongly Binding, Rapidly Complexing, Ion Selective Spherands

Cyclic urea units bound to anisyl or methylene units have been incorporated into 20-membered ring hosts whose complexation of alkali metal and ammonium ions show high binding free energies, high extraction rates, and high ion selectivities.