84393-05-5Relevant academic research and scientific papers
Degradation of aldehydes to one carbon lower homologs
Belotti, Damien,Andreatta, Ga?lle,Pradaux, Fabienne,BouzBouz, Samir,Cossy, Janine
, p. 3613 - 3615 (2007/10/03)
Degradation of aldehydes to one carbon lower homologs has been achieved by using a mixture of N-methylmorpholine, N-methylmorpholine N-oxide, a catalytic amount of OsO4 and NaIO4 in a mixture of acetone/H2O.
Tetramethyl 1,1,4,4-Cyclohexanetetracarboxylate: Preparation and Conversion to Key Precursors of Fluorinated, Stereochemically Defined Cyclohexanes
Davis, Charles R.,Swenson, Dale C.,Burton, Donald J.
, p. 6843 - 6850 (2007/10/02)
Stereoselective low-temperature diisobutylaluminum hydride (DIBALH) reduction of the litle tetraester 3 affords trans-1,4-dialdehyde 4a as the major product.Fluorination of 4a,b, followed by additional elaboration leads to novel, 1,1,4,4-tetrasubstituted cyclohexanes bearing trans-1,4-difluoromethyl and fluoromethyl groups.The effect of ring size and number of ester substituents on the outcome of the reduction has been examined and treatment of dimethyl 1,1-cycloalkyl diesters 7a-c with excess DIBALH results in reduction of only one ester group.An entry into trans-1,4-trifluoromethylated tetrasubstituted cyclohexanes has been gained through stereoselective SF4 fluorination of 1,1,4,4-cyclohexanetetracarboxylic acid 17.Stereochemical assignments are supported by X-ray crystallographic data.
Vilsmeier Formylation of O-Silylated Enolates of Carboxylic Esters. A New Method for the Synthesis of α-Formylcarboxylic Esters
Reddy, Chaganti P.,Tanimoto, Shigeo
, p. 575 - 577 (2007/10/02)
The Vilsmeier formylation of ketene O-alkyl O'-silyl acetals (O-silylated enolates of carboxylic esters) provides α-formylcarboxylic esters in moderate yields.
Novel α-Formylation of α,α-Disubstituted Esters. Trimethylsilyl Trifluoromethanesulfonate-catalysed Reaction of Ketene Silyl Acetals with N-t-Butylformimidoyl Cyanide
Okano, Kohji,Morimoto, Toshiaki,Sekiya, Minoru
, p. 119 - 120 (2007/10/02)
General α-formylation of α,α-disubstituted methyl acetates can be achieved by the reaction of ketene silyl acetals (1) with N-t-butylformimidoyl cyanide (2) in the presence of trimethylsilyl trifluoromethanesulphonate (3) as catalyst followed by hydrolysi
