844-66-6Relevant academic research and scientific papers
Impact of mono- and disubstitution on the colorimetric dynamic covalent switching chalcone/flavanone scaffold
Muller, Brian M.,Mai, Jesse,Yocum, Reid A.,Adler, Marc J.
supporting information, p. 5108 - 5114 (2014/07/08)
The effect of aryl substitution on various aspects of the interconversion of ortho-hydroxychalcones and flavanones has been studied using multiple spectroscopic techniques. Derivatization of the core scaffold predictably alters the midpoint pH of this equilibration process suggesting its viability for application as a functional colorimetric molecular switch.
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
Chimenti, Franco,Fioravanti, Rossella,Bolasco, Adriana,Chimenti, Paola,Secci, Daniela,Rossi, Francesca,Yá?ez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano,Cirilli, Roberto,Ferretti, Rosella,Sanna, M. Luisa
experimental part, p. 1273 - 1279 (2010/04/24)
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
