392-08-5Relevant academic research and scientific papers
Synthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents
Abdellatif, Khaled R. A.,Elshemy, Heba A. H.,Salama, Samir A.,Omar, Hany A.
, p. 484 - 491 (2015)
In an effort to develop safe and potent anti-inflammatory agents, a series of novel 4′-fluoro-2′-hydroxychalcones 5a-d and their dihydropyrazole derivatives 6a-d was prepared. It was synthesized via aldol condensation of 4′-fluoro-2′-hydroxyacetophenone w
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents
Britton, Robert G.,Horner-Glister, Emma,Pomenya, Odette A.,Smith, Ewan E.,Denton, Roanne,Jenkins, Paul R.,Steward, William P.,Brown, Karen,Gescher, Andreas,Sale, Stewart
experimental part, p. 952 - 958 (2012/10/08)
A library of flavonol analogues was synthesised and evaluated as potential anticancer agents against a human prostate cancer cell line, 22rν1. Compounds 3, 8 and 11 (IC50 2.6, 3.3 and 4.0 μM respectively) showed potent cancer cell growth inhibi
Pyrrolidylsubstituted azadipyrromethene with fully chelated boron atom
Yakubovskyi, Viktor P.,Shandura, Mykola P.,Kovtun, Yuriy P.
scheme or table, p. 944 - 950 (2010/06/12)
A difluorosubstituted aza-boron-dipyrromethene derivative with fully chelated boron atom was synthesized by the reaction of BF3Et 2O with 3,3,5,5-tetraarylazadipyrromethene, which was easily prepared from 1,3-diaryl-4-nitro-butan-1-one and ammonium acetate. One fluorine atom of the dye was substituted by pyrrolidine residue. This resulted in a significant bathochromic effect. Ultraviolet absorption and fluorescence emission spectra were recorded, and quantum yields of the obtained compounds were calculated.
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
Chimenti, Franco,Fioravanti, Rossella,Bolasco, Adriana,Chimenti, Paola,Secci, Daniela,Rossi, Francesca,Yá?ez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano,Cirilli, Roberto,Ferretti, Rosella,Sanna, M. Luisa
experimental part, p. 1273 - 1279 (2010/04/24)
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
