84401-16-1 Usage
Description
1H-Indole-4-acetic acid, ethyl ester, also known as Ethyl indole-4-acetate, is an organic compound with the chemical formula C12H11NO2. It is a derivative of indole-4-acetic acid, an auxin-like plant hormone, and is characterized by the presence of an ethyl ester group. 1H-Indole-4-acetic acid, ethyl ester exhibits unique chemical and biological properties, making it a versatile molecule for various applications.
Uses
Used in Pharmaceutical Industry:
1H-Indole-4-acetic acid, ethyl ester is used as a reactant in the preparation of substituted bisthiadiazoles, which are glutaminase inhibitors. These inhibitors are useful in the treatment of cancer, as they target the enzyme glutaminase, which plays a crucial role in cancer cell metabolism and growth. By inhibiting glutaminase, these compounds can potentially disrupt the energy supply and survival of cancer cells, leading to their death.
Check Digit Verification of cas no
The CAS Registry Mumber 84401-16-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,0 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 84401-16:
(7*8)+(6*4)+(5*4)+(4*0)+(3*1)+(2*1)+(1*6)=111
111 % 10 = 1
So 84401-16-1 is a valid CAS Registry Number.
84401-16-1Relevant articles and documents
SYNTHESIS OF 4-( CYANOMETHYLIDENE)- AND 4-( ETHOXYCARBONYLMETHYLIDENE)-4,5,6,7-TETRAHYDROINDOLES AND THEIR DEHYDROGENATION TO 4-( CYANOMETHYL)- AND 4-( ETHOXYCARBONYLMETHYL)INDOLES
Matsumoto, Masakatsu,Watanabe, Nobuko
, p. 2611 - 2618 (2007/10/02)
The Horner-Wittig reaction of 4-oxo-4,5,6,7-tetrahydroindoles with (EtO)2P(O)CH2CN and (EtO)2P(O)CH2CO2Et yielded respectively 4-(cyanomethylidene)- and 4-(ethoxycarbonylmethylidene)-4,5,6,7-tetrahydroindoles, which were catalytically dehydrogenated to 4-
