84401-16-1

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-4-acetic acid, ethyl ester is used as a reactant in the preparation of substituted bisthiadiazoles, which are glutaminase inhibitors. These inhibitors are useful in the treatment of cancer, as they target the enzyme glutaminase, which plays a crucial role in cancer cell metabolism and growth. By inhibiting glutaminase, these compounds can potentially disrupt the energy supply and survival of cancer cells, leading to their death.

Upstream product

• 64-17-5 ethanol 
• 84401-14-9 1-benzoyl-4-diazoacetylindole 
• 107170-60-5 4-(ethoxycarbonylethylidene)-4,5,6,7-tetrahydroindole 
• 344320-85-0 1-Benzoyl-1H-indole-4-carbonyl chloride 
• 84401-13-8 1-benzoylindole-4-carboxylic acid 
• 84401-12-7 benzyl 1-benzoylindole-4-carboxylate 
• 84401-11-6 benzyl indole-4-carboxylate 
• 2124-55-2 1H-indole-4-carboxylic acid 

Relevant academic research and scientific papers

SYNTHESIS OF 4-( CYANOMETHYLIDENE)- AND 4-( ETHOXYCARBONYLMETHYLIDENE)-4,5,6,7-TETRAHYDROINDOLES AND THEIR DEHYDROGENATION TO 4-( CYANOMETHYL)- AND 4-( ETHOXYCARBONYLMETHYL)INDOLES

The Horner-Wittig reaction of 4-oxo-4,5,6,7-tetrahydroindoles with (EtO)2P(O)CH2CN and (EtO)2P(O)CH2CO2Et yielded respectively 4-(cyanomethylidene)- and 4-(ethoxycarbonylmethylidene)-4,5,6,7-tetrahydroindoles, which were catalytically dehydrogenated to 4-

Synthesis of N-Alkyl Derivatives of 4-(2'-Aminoethyl)indole

N-Substituted 4-(2'-aminoethyl)indoles are attainable in good yields from indole-4-acetic acid (2).Several methods of preparation for 2 were tried or considered.A new sequence involving Arndt-Eistert homologation of indole-4-carboxylic acid has been devis