84404-69-3

Upstream product

• 10338-69-9 1,2,3,6-tetrahydro-4-phenylpyridine 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 134133-55-4 6-<3-(4-phenyl-1,2,3,6-pyridyl)propyl>-6H-dibenz-1,2-thiazine 5,5-dioxide 
• 134133-51-0 N-<3-(4-phenyl-1,2,3,6-tetrahydropyridyl)propyl>benzindol-2-(1H)-one 
• 134133-53-2 N-<3-(4-phenyl-1,2,3,6-tetrahydropyridyl)propyl>-N-phenylbenzenesulfonamide 
• 134133-67-8 6-<3-(4-phenyl-1,2,3,6-pyridyl)propyl>-6H-dibenz-1,2-thiazine 5,5-dioxide oxalate 
• 134133-54-3 N-methyl-N-<3-(4-phenyl-1,2,3,6-tetrahydropyridyl)propyl>-1-naphthalenesulfonamide 

Relevant academic research and scientific papers

Preparation of novel derivatives of pyridothiazine-1,1-dioxide and their CNS and antioxidant properties.

Starting from isothiazolopyridine-1,1-dioxide (1), corresponding derivatives of 3-aryl-4-hydroxypyrido[3,2-e]-1,2-thiazine-1,1-dioxide (6) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or 3-(4-substituted-piperidinyl)propyl side chain by the

Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them

This invention relates to a compound STR1 in which R 1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical.a 1-piperazinyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxy, nitro or amino radical or a halogen atom, (c) a 1,2-benzisothiazol-3-yl radical, (d) a 1,2-benzisoxazol-3-yl radical or (e) a 2-pyridyl radical.a piperidino radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or a hydroxy, alkyl or alkoxy radical, (c) two phenyl radicals, (d) a bis(4-fluorophenyl)methylene radical, (e) a 4-fluorobenzoyl radical, (f) a 2-oxo-1-benzimidazolinyl radical, (g) a 2-oxo-1-benzimidazolinyl radical substituted in the 3-position by an alkylcarbonyl or benzoyl radical, (b) a hydroxy radical and a phenyl radical optionally substituted with an alkyl, alkoxy or hydroxy radical or a halogen atom, (i) a 3-indolyl radical, (j) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (k) a 3-(5-hydroxyindolyl) radical.either:R 2 and R 3, which are identical, represent a hydrogen or halogen atom and R 4 represents a hydrogen atom orR 2 and R 4 represent a hydrogen atom and R 3 represents a halogen atom or an acetylamino radical orR 2 and R 3 represent a hydrogen atom and R 4 represents a halogen atom and R 5 represents a --CH group.or R 2, R 3 and R 4 represent a hydrogen atom and R 5 represents a nitrogen atom.R 6 represents an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in the 1- or 3-position by an alkyl radical or in the 2-position by an alkyl, alkoxy, hydroxy, dialkylamino, piperidino, morpholino or thiomorpholino radical,with the reservation that when R 6 represents a propylene radical substituted in the 2-position by a dialkylamino, piperidino, morpholino or thiomorpholino radical, R 1 cannot be a radical containing a hydroxy radical, and their salts, are useful in therapy for their ability to block serotonin receptors.

Naphthosultam Derivatives: A New Class of Potent and Selective 5-HT2 Antagonists

A series of 2-(aminoalkyl)naphthisothiazole 1,1-dioxides was synthesized and examined in various receptor binding tests.Most compounds demonstrated high affinity for the 5-HT2 receptor with moderate to high selectivity.A member of this