84422-37-7Relevant academic research and scientific papers
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents
Vijaya Bhaskar Reddy,Shen, Yuh-Chiang,Ohkoshi, Emika,Bastow, Kenneth F.,Qian, Keduo,Lee, Kuo-Hsiung,Wu, Tian-Shung
experimental part, p. 97 - 103 (2012/03/08)
Chalcones have a distinctive 1,3-diarylpropenone skeleton and exert numerous biological effects. Using a one-step Claisen-Schmidt condensation, we synthesized eleven bis-chalcones (3-13) and three acetyl chalcones (14-16) from substituted aldehydes and diacetylresorcinol. The compounds were tested for in vitro cytotoxic activity against four human cancer cell lines (A549, DU145, KB, and KB-VIN) and inhibition of NO production in lipopolysaccharide (LPS)-activated microglial cells. Among them, four compounds (3, 5, 6, and 13) showed significant cytotoxic activity with EC50 values ranging from 1.57 to 5.14 μM, and seven compounds (3, 5-8, 10, and 13) displayed potent anti-inflammatory activity by inhibiting NO production with IC50 values ranging from 0.95 to 8.65 μM. A mechanism of action study of active compounds 6 and 7 discovered that these compounds down-regulated iNOS expression by inhibiting p65 NF-κB activation/nuclear translocation due to prevention of IκBα degradation. Structure-activity relationship (SAR) findings are also discussed.
A facile synthesis of 3,7-diphenyl-4,6-distyryl-2,8-dioxo-2h,8h- benzo(1,2-b:5,4-b')dipyrans and their antifeedant activity
Sreenivasulu,Sarma
, p. 2281 - 2287 (2007/10/03)
The synthesis, characterisation and antifeedant activity of some new dicoumarins prepared from 4,6-diacetyl resorcinol has been reported.
Synthesis of 4,6-Bis(2'-substituted-2',3'-dihydro-1,5-benzothiazepin-4'-yl) resorcinols as potential antifeedants
Reddy, R Jayasimha,Ashok, D,Sarma, P N
, p. 404 - 406 (2007/10/02)
4,6-Bis(2'-substituted-2',3'-dihydro-1,5-benzothiazepin-4'-yl) resorcinols (3a-j) have been prepared in one step by the reaction of dichalcones (2a-j) with 2-aminothiophenol in ethanol containing gl. acetic acid and their structures established by element
Synthesis of Some Benzodipyrones from 4,6-Diacetylresorcinol
Anjaneyulu, A. S. R.,Mallavadhani, U. V.,Venkateswarlu, Y.
, p. 963 - 964 (2007/10/02)
Some α- and γ-benzodipyrones have been prepared in very good yield from 4,6-diacetylresorcinol (I) and characterised by their spectral data.
Homobiflavonoids from 5-Acetyl- and 3-Acetyl-resacetophenones
Mohan, Santosh Bala,Pal, Krishan,Murti, V. V. S.
, p. 714 - 717 (2007/10/02)
Reaction of 5- and 3-acetyl-resacetophenones with formaldehyde under acidic conditions yields the bis-methylene derivatives (V) and (XIa), respectively in good yields.These have been condensed with benzaldehyde to obtain the corresponding chalkones, which
