84443-23-2Relevant academic research and scientific papers
N-OXIDES OF 2- AND 4-AZAFLUORENONES AND NITRO DERIVATIVES
Prostakov, N. S.,Shendrik, I. V.,Anisimov, B. N.,Varlamov, A. V.,Fomichev, A. A.,Lavani-Edogiaverie, S.
, p. 1085 - 1088 (1982)
It was demonstrated by PMR spectroscopy that mixtures of N-oxides of 6- and 7- nitro derivatives are formed in the nitration of the N-oxides of 3-methyl-2- and 4-azafluorenes.The products were deoxygenated to give nitro derivatives of 2- and 4-azafluorenes.The N-oxides of nitro-substitited azafluorenes ware converted to salts of the aci forms by the action of alkali.
Sequential C-H and C-C Bond Cleavage: Divergent Constructions of Fused N-Heterocycles via Tunable Cascade
Li, Xianwei,Rao, Jianhang,Ouyang, Wensen,Chen, Qian,Cai, Ning,Lu, Yu-Jing,Huo, Yanping
, p. 8749 - 8756 (2019/09/30)
Streamlining the generation of diverse highly functionalized molecules from abundant feedstocks holds great synthetic promises and challenges in pharmaceutical and material discovery. Herein, we report a tunable selectivity in multiple cascade reactions for the divergent assembly of fused N-heterocycles, comprising sequential activation of C-H and C-C bonds. Isolatable indene-type intermediates might be responsible for the generation of densely substituted fused pyridines, azepines, and azafluorenones products. The tolerance of strongly coordinating N-heterocycles, and those readily applicable for the late-stage modifications of pharmaceuticals and material molecules precursors, further demonstrated the synthetic robustness of this transformation.
