84445-92-1

Basic information

• Product Name: 2'-Amino-6'-methylacetanilide
• Synonyms: 2-Acetylamino-m-toluidine;2'-Amino-6'-methylacetanilide;N-(2-Amino-6-methylphenyl)acetamide
• CAS NO: 84445-92-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Mol File: 84445-92-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-Amino-6'-methylacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Amino-6'-methylacetanilide(84445-92-1)
• EPA Substance Registry System: 2'-Amino-6'-methylacetanilide(84445-92-1)

Safety Data

• Hazardous Substances Data: 84445-92-1(Hazardous Substances Data)

Usage

Appearance

Pale yellow solid

Melting Point

80-81°C

Solubility

Slightly soluble in water, soluble in organic solvents

Applications

Used in the production of dyes
Utilized in pharmaceutical synthesis
Employed as a component in rubber accelerators

Precursor

Utilized in the synthesis of various pharmaceutical products

Potential Use

Investigated for its antioxidant properties

Safety Concerns

Harmful if ingested or inhaled
Can cause skin irritation upon contact

Upstream product

• 59907-22-1 N-(2-methyl-6-nitrophenyl)acetamide 
• 82344-53-4 N,N-diacetyl-6-nitro-o-toluidine 
• 570-24-1 2-Methyl-6-nitroaniline 

Downstream Products

• 21352-09-0 N-(6-chloro-2-methylphenyl)acetamide 
• 84445-91-0 1-acetyl-7-methylbenzimidazole 
• 84445-81-8 1-acetyl-4-methylbenzimidazole 
• 27231-33-0 7-methyl-1H-benzo[d]imidazole-2-thiol 
• 84445-89-6 1-acetyl-7-methyl-2-benzimidazolethiol 

Relevant articles and documents

Synthesis method of key raw material 2-chloro-6-methylaniline of dasatinib

The invention discloses a synthetic method of a key raw material 2-chloro-6-methylaniline of dasatinib. The method comprises the following steps: firstly, protecting a 1-site amino group of 2-nitro-6-methylaniline, then reducing a 2-site nitro group of 2-nitro-6-methylaniline into an amino group, then carrying out diazotization reaction, carrying out chlorine substitution on the 2-site amino group by using cuprous chloride, and finally, carrying out acidolysis to remove a 1-site amino protecting group to obtain 2-chlorine-6-methylaniline. The method has the advantages of cheap and easily available raw materials, easily controllable reaction, simple operation steps, simple post-treatment, recyclable solvents, small pollution, and suitableness for large-scale production of generative enterprises.