59907-22-1

Basic information

• Product Name: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE
• Synonyms: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE;Acetamide, N-(2-methyl-6-nitrophenyl)-;4-(4-chlorophenoxy)-3,5-difluorobenzene-1-sulfonyl chloride;6'-NITRO-ORTHO-ACETOTOLUIDIDE;2’-Methyl-6’-nitroacetanilide
• CAS NO: 59907-22-1
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 59907-22-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 375.3 °C at 760 mmHg
• Flash Point: 180.8 °C
• Appearance: /
• Density: 1.289 g/cm³
• Vapor Pressure: 7.87E-06mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE(59907-22-1)
• EPA Substance Registry System: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE(59907-22-1)

Safety Data

• Hazardous Substances Data: 59907-22-1(Hazardous Substances Data)

Usage

General Description

N-(2-Methyl-6-nitro-phenyl)-acetamide is a chemical compound with the molecular formula C9H10N2O3. It is a yellow solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE has a nitro group and a methyl group attached to a phenyl ring, as well as an acetamide group. It is important to handle this chemical with care as it may be harmful if ingested, inhaled, or absorbed through the skin. Additionally, it is also important to store and dispose of it in a safe and environmentally responsible manner.

InChI:InChI=1/C9H10N2O3/c1-6-4-3-5-8(11(13)14)9(6)10-7(2)12/h3-5H,1-2H3,(H,10,12)

Upstream product

• 120-66-1 N-(2-methylphenyl)acetamide 
• 108-24-7 acetic anhydride 
• 95-53-4 o-toluidine 
• 570-24-1 2-Methyl-6-nitroaniline 
• 60-35-5 acetamide 
• 41085-43-2 2-bromo-3-nitrotoluene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 82344-53-4 N,N-diacetyl-6-nitro-o-toluidine 

Downstream Products

• 56207-35-3 acetic acid-(2-methyl-4,6-dinitro-anilide) 
• 86560-87-4 2,2'-diamino-6,6'-dimethylbiphenyl 
• 87-63-8 2-chloro-6-methylaniline 
• 3685-05-0 (S)-6,6'-dimethyl-2,2'-diaminobiphenyl 
• 3685-05-0 (Ra)-6,6'-dimethyl-1,1'-biphenyl-2,2'-diamine 
• 570-24-1 2-Methyl-6-nitroaniline 
• 2719-15-5 2-methyl-4-nitroacetanilide 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 41085-43-2 2-bromo-3-nitrotoluene 
• 54879-20-8 2-bromo-3-methylaniline 
• 102312-37-8 2,3,5-trinitro-benzoic acid 
• 66583-76-4 2-bromo-3,5-dinitro-toluene 
• 7477-94-3 2-methyl-4,6-dinitroaniline 
• 609-97-2 2-amino-3,5-dinitro-benzoic acid 

Relevant articles and documents

Synthesis method of key raw material 2-chloro-6-methylaniline of dasatinib

The invention discloses a synthetic method of a key raw material 2-chloro-6-methylaniline of dasatinib. The method comprises the following steps: firstly, protecting a 1-site amino group of 2-nitro-6-methylaniline, then reducing a 2-site nitro group of 2-nitro-6-methylaniline into an amino group, then carrying out diazotization reaction, carrying out chlorine substitution on the 2-site amino group by using cuprous chloride, and finally, carrying out acidolysis to remove a 1-site amino protecting group to obtain 2-chlorine-6-methylaniline. The method has the advantages of cheap and easily available raw materials, easily controllable reaction, simple operation steps, simple post-treatment, recyclable solvents, small pollution, and suitableness for large-scale production of generative enterprises.

Axially Chiral Bifunctional 8,8′-Biquinolyl: Synthesis of 7,7′-Dihydroxymethyl-8,8′-biquinolyl via Pd-Catalyzed Double C-H Oxidation of 7,7′-Dimethyl-8,8′-biquinolyl

Bifunctional C2-symmetric 7,7′-dihydroxymethyl-8,8′-biquinolyl (2) was synthesized in short steps via (i) Cu/Pd-catalyzed homo coupling of 7-methyl-8-bromoquinoline and (ii) Pd(II)-catalyzed double C-H oxidation. Axial chirality of 2 and its synthetic precursor 7,7′-dimethyl-8,8′-biquinolyl (3) is stable. Optically active 2 was obtained through separation of racemic 2 by chiral column HPLC or Pd(II)-catalyzed double C-H oxidation of optically active 3. The absolute stereochemistry of enantiomers of 2 and 3 was determined using the exciton chirality method.

Discovery and optimization of benzotriazine Di-N-oxides targeting replicating and nonreplicating mycobacterium tuberculosis

Compounds bactericidal against both replicating and nonreplicating Mtb may shorten the length of TB treatment regimens by eliminating infections more rapidly. Screening of a panel of antimicrobial and anticancer drug classes that are bioreduced into cytotoxic species revealed that 1,2,4-benzotriazine di-N-oxides (BTOs) are potently bactericidal against replicating and nonreplicating Mtb. Medicinal chemistry optimization, guided by semiempirical molecular orbital calculations, identified a new lead compound (20q) from this series with an MIC of 0.31 μg/mL against H37Rv and a cytotoxicity (CC 50) against Vero cells of 25 μg/mL. 20q also had equivalent potency against a panel of single-drug resistant strains of Mtb and remarkably selective activity for Mtb over a panel of other pathogenic bacterial strains. 20q was also negative in a L5178Y MOLY assay, indicating low potential for genetic toxicity. These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.