84453-60-1Relevant articles and documents
Photochemically controlled cross-linking in polymerized crystalline colloidal array photonic crystals
Kamenjicki, Marts,Asher, Sanford A.
, p. 8293 - 8296 (2004)
We developed photochemically controlled photonic crystals which may be useful in novel recordable and erasable memories and/or display devices. Information is recorded and erased by exciting the photonic crystal with ～360 nm UV light or ～480 nm visible li
On the permeation of large organic cations through the pore of ATP-gated P2X receptors
Harkat, Mahboubi,Peverini, Laurie,Cerdan, Adrien H.,Dunning, Kate,Beudez, Juline,Martz, Adeline,Calimet, Nicolas,Specht, Alexandre,Cecchini, Marco,Chataigneau, Thierry,Grutter, Thomas
, p. E3786 - E3795 (2017/05/15)
Pore dilation is thought to be a hallmark of purinergic P2X receptors. The most commonly held view of this unusual process posits that under prolonged ATP exposure the ion pore expands in a striking manner from an initial small-cation conductive state to a dilated state, which allows the passage of larger synthetic cations, such as N-methyl-D-glucamine (NMDG+). However, this mechanism is controversial, and the identity of the natural large permeating cations remains elusive. Here, we provide evidence that, contrary to the time-dependent pore dilation model, ATP binding opens an NMDG+-permeable channel within milliseconds, with a conductance that remains stable over time. We show that the time course of NMDG+ permeability superimposes that of Na+ and demonstrate that the molecular motions leading to the permeation of NMDG+ are very similar to those that drive Na+ flow. We found, however, that NMDG+ percolates 10 times slower than Na+ in the open state, likely due to a conformational and orientational selection of permeating molecules. We further uncover that several P2X receptors, including those able to desensitize, are permeable not only to NMDG+ but also to spermidine, a large natural cation involved in ion channel modulation, revealing a previously unrecognized P2X-mediated signaling. Altogether, our data do not support a time-dependent dilation of the pore on its own but rather reveal that the open pore of P2X receptors is wide enough to allow the permeation of large organic cations, including natural ones. This permeation mechanismhas considerable physiological significance.
New azobenzene derivatives for directed modification of proteins
Hien, Le Thi,Schierling,Ryazanova,Zatsepin,Volkov,Kubareva,Velichko,Pingoud,Oretskaya
body text, p. 549 - 555 (2010/08/22)
Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compound
Synthesis of new bis(tetrahydropyrrolo[3,4-b]carbazoles) with a functionalized diaryl spacer
Mehrabani,Pindur
, p. 1406 - 1412 (2007/10/03)
Some new bis(tetrahydropyrrolo[3,4-b]carbazoles) were synthesized by Diels-Alder reactions of in-situ generated indole-2,3-quinodimethanes with a variety of bismaleimides as dienophiles and also by reaction of dianilines with a succinic acid anhydride group incorporated into a biscarbazole. In a special reaction a spermine linker was introduced. The new biscarbazoles represent potential DNA ligands for the development of new antitumor active drugs.
