84466-39-7

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 111873-50-8 dibutyl(cyanomethyl)telluronium chloride 
• 75-05-8 acetonitrile 
• 40018-25-5 2-Chlorobenzoyl acetonitrile 
• 5000-66-8 2-chlorophenacyl bromide 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 62717-50-4 o-chlorostyrene oxide 
• 2039-87-4 2-chlorostyrene 
• 90712-55-3 5-(2-chlorophenyl)-4,5-dihydroisoxazole 

Downstream Products

• 704-96-1 trans-2-chlorocinnamic acid 

Relevant academic research and scientific papers

Biocatalytic asymmetric ring-opening of dihydroisoxazoles: a cyanide-free route to complementary enantiomers of β-hydroxy nitriles from olefins

By combination of the cyanide-free synthesis of chiral nitriles and the Kemp elimination reaction catalyzed by aldoxime dehydratases, we herein report a new application of aldoxime dehydratase in the asymmetric ring-opening of 5-sub-4,5-dihydroisoxazoles

NEW TRPA1 ANTAGONISTS

The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

Hydroxylated sulfamides exhibiting neuroprotective action and their method of use

Pharmaceutical compositions of the invention include hydroxylated sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's dise

N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN

N-Heterocyclic carbenes (NHCs) have been served as efficient catalysts for cyanomethylation of carbonyl compounds. In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give β-hydroxynitriles in moderate to high yields.

P(i-PrNCH2CH2)3N as a Lewis base catalyst for the synthesis of β-hydroxynitriles using TMSAN

(Equation Presented) Proazaphosphatrane 1a was found to be an efficient catalyst for synthesis of β-hydroxynitriles via the reaction of trimethylsilylacetonitrile (TMSAN) with aldehydes under mild reaction conditions and typically low catalyst loading (ca. 2 mol %). A variety of functional groups were tolerated, and good to excellent product yields were obtained.

RhI-catalyzed aldol-type reaction of organonitriles under mild conditions

An aldol-type reaction of organonitriles with aldehydes was catalyzed by a RhI(OR) species under ambient conditions, and the reaction displayed a broad substrate scope with respect to both organonitrile and aldehyde components. The Royal Societ

Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of β-hydroxy nitriles

Biocatalytic enantioselective hydrolysis of β-hydroxy nitriles to corresponding (S)-enriched β-hydroxy carboxylic acids has been achieved for the first time by an isolated nitrilase bII6402 from Bradyrhizobium japonicum USDA110. This offers a new "green" approach to optically pure β-hydroxy nitriles and β-hydroxy carboxylic acids. The observed remote stereorecognition is surprising because this nitrilase shows no enantioselectivity for the hydrolysis of α-hydroxy nitriles such as mandelonitrile.

Novel Reaction of Dibutyl(cyanomethyl)telluronium Chloride with Carbonyl Compounds Mediated by Organolithium Reagents: Highly Efficient Synthesis of β-Hydroxy Nitriles

Dibutyl(cyanomethyl)telluronium chloride, a precursor of stabilized telluronium ylides, after being treated with organolithium reagents reacted with carbonyl compounds to afford β-hydroxy nitriles instead of α,β-unsaturated nitriles in excellent yields.

AN ALDOL-TYPE REACTION OF ACETONITRILES USING DIALKYLBORYL TRIFLATE

Acetonitriles and benzaldehydes react in the presence of dialkyl boryl triflate and diisopropylethylamine in dichloromethane to give the corresponding aldol-type products in good yields under mild conditions.