84466-86-4Relevant academic research and scientific papers
Ruthenium Catalyzed N-Alkylation of Cyclic Amines with Primary Alcohols
Savela, Risto,Vogt, Dieter,Leino, Reko
, p. 3030 - 3040 (2020/05/22)
A robust alcohol amination protocol using common saturated amines and primary alcohols as starting materials is described. The reactions are catalyzed by combination of dichloro(p-cymene)ruthenium(II) dimer precatalyst with triphenylphosphine ligand, with
The phosphate-carboxylate mixed-anhydride method: A mild, efficient process for ester and amide bond construction
McNulty, James,Vemula, Ramesh,Krishnamoorthy, Venkatesan,Robertson, Al
, p. 5415 - 5421 (2012/09/08)
A highly efficient carboxylate-phosphate anhydride pathway is described for the direct, economical synthesis of esters and amides from carboxylic acids and alcohols or amines. The reaction proceeds with retention of configuration with both chiral secondary alcohols and α-amino acid derivatives allowing access to useful chiral auxiliaries, ligands, and organocatalysts. Ester and amide products can be isolated directly in high yield due to the water soluble nature of the side products.
