844866-93-9Relevant academic research and scientific papers
Enantioselective synthesis of β-fluoroamines from β-amino alcohols: Application to the synthesis of LY503430
Duthion, Beranger,Pardo, Domingo Gomez,Cossy, Janine
supporting information; experimental part, p. 4620 - 4623 (2010/12/19)
N,N-Dialkyl-β-amino alcohols were enantiospecifically and regioselectively rearranged by using N,N-diethylaminosulfur trifluoride (DAST) to give optically active β-fluoroamines in excellent yields and enantiomeric excesses. This rearrangement was applied to the enantioselective synthesis of LY503430, a potential therapeutic agent for Parkinson's disease.
Enantiocontrolled synthesis of α-methyl amino acids via Bn 2N-α-methylserine-β-lactone
Smith, Nicole D.,Wohlrab, Aaron M.,Goodman, Murray
, p. 255 - 258 (2007/10/03)
(Chemical Equation Presented) Enantiocontrolled synthesis of α-methyl amino acids proceeds via the regioselective organocuprate opening of Bn 2N-α-methylserine-β-lactone. From this chiral intermediate, a wide variety of α-methyl amino acids and
