845271-73-0

Basic information

• Product Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine
• Synonyms: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine
• CAS NO: 845271-73-0
• Molecular Weight: 379.821
• Mol File: 845271-73-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine(845271-73-0)
• EPA Substance Registry System: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine(845271-73-0)

Safety Data

• Hazardous Substances Data: 845271-73-0(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 944549-41-1 N-[3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-bromo-quinazolin-4-amine 

Relevant articles and documents

Synthesis of Lapatinib via direct regioselective arylation of furfural

A new synthesis of Lapatinib, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.