845276-75-7

Basic information

• Product Name: Methanone, (2-aminophenyl)(2-bromophenyl)-
• CAS NO: 845276-75-7
• Molecular Formula: C13H10BrNO
• Molecular Weight: 276.132
• Mol File: 845276-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (2-aminophenyl)(2-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-aminophenyl)(2-bromophenyl)-(845276-75-7)
• EPA Substance Registry System: Methanone, (2-aminophenyl)(2-bromophenyl)-(845276-75-7)

Safety Data

• Hazardous Substances Data: 845276-75-7(Hazardous Substances Data)

Usage

General Description

Methanone, (2-aminophenyl)(2-bromophenyl)-, also known as 2-Amino-2′-bromobenzophenone, is a chemical compound with the molecular formula C13H9BrNO. It is a ketone compound that consists of a benzophenone core with an amino group attached to one phenyl ring and a bromine atom attached to the other phenyl ring. Methanone, (2-aminophenyl)(2-bromophenyl)- is commonly used in organic synthesis and pharmaceutical research as a building block for creating various drugs and pharmaceutical products. It is also utilized in the production of dyes, pigments, and other industrial chemicals. Additionally, it has potential applications in materials science and as a reagent in chemical reactions.

Upstream product

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Relevant articles and documents

Preparation method of 1-bromofluorenone

The invention discloses a preparation method of 1-bromo fluorenone, and belongs to the field of organic chemical synthesis. The method is realized by the following steps of: reacting 2-bromophenyl acetonitrile serving as an initial raw material with nitrobenzene to synthesize 3-(2-bromophenyl)-5-benzoisoxazole; reducing 3-(2-bromophenyl)-5-benzoisoxazole by iron powder to obtain 2-aminobenzene-2'-bromobenzophenone, and finally performing intramolecular cyclization to synthesize 1-bromofluorenone with the content of 99.5% (HPLC) or above and the total yield of 76% or above. The synthesis methodis low in production cost and suitable for industrial production, and 1-bromofluorenone can be used in the fields of organic photoelectric materials, biomedicines and dyes.

Pd-NHC catalysed Carbonylative Suzuki coupling reaction and its application towards the synthesis of biologically active 3-aroylquinolin-4 (1H)-one and acridone scaffolds

We have unfolded a convenient and mild protocol for the synthesis of diaryl ketones via Pd- NHC catalysed carbonylative Suzuki coupling reaction. Notably, this method offers advantages like no use of toxic CO gas, shorter reaction time, high yield, and broad substrate scope. Several sensitive functional groups (like-COMe, -COOMe, -F, -Cl, -Br, -NH2, -CN) are well tolerated in this reaction. In addition, we have also demonstrated a new efficient route for the synthesis of biologically active and pharmaceutically important 2-substituted 3-Aroylquinolin-4(1H)-ones and acridone scaffolds.