845292-32-2Relevant academic research and scientific papers
Compounds for treating tumors
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Page 47, (2008/06/13)
The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
Synthesis and biological activity of analogues of the antimicrotubule agent N,β,β-trimethyl-L-phenylalanyl-N1-[(1S,2E)-carboxy-1- isopropylbut-2-enyl]-N13-dimethyl-L-valinamide (HTI-286)
Zask, Arie,Birnberg, Gary,Cheung, Katherine,Kaplan, Joshua,Niu, Chuan,Norton, Emily,Suayan, Ronald,Yamashita, Ayako,Cole, Derek,Tang, Zhilian,Krishnamurthy, Girija,Williamson, Robert,Khafizova, Gulnaz,Musto, Sylvia,Hernandez, Richard,Annable, Tami,Yang, Xiaoran,Discafani, Carolyn,Beyer, Carl,Greenberger, Lee M.,Loganzo, Frank,Ayral-Kaloustian, Semiramis
, p. 4774 - 4786 (2007/10/03)
Hemiasterlin (1), a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286 (2), an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its potent
