84538-49-8

Usage

General Description

2-(piperidine-1-carbonyl)benzaldehyde is a chemical compound with the molecular formula C16H17NO2. It is an aldehyde derivative that contains a piperidine ring and a benzene ring, as well as a carbonyl group attached to the piperidine ring. This chemical is commonly used as a building block in organic synthesis and medicinal chemistry. It can be used as a key intermediate in the synthesis of various pharmaceuticals, such as antihistamines and antidepressants. Additionally, it has been studied for its potential as an anti-inflammatory and anti-cancer agent. Overall, 2-(piperidine-1-carbonyl)benzaldehyde has important applications in the fields of drug discovery and medicinal chemistry.

Upstream product

• 110-89-4 piperidine 
• 61296-43-3 3-Iodo-1(3H)-isobenzofuranone 
• 6940-49-4 3-Bromophthalide 
• 87-41-2 2-benzofuran-1(3H)-one 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 33388-67-9 (2-methyl-phenyl)-(piperidin-1-yl)methanone 
• 119-67-5 o-carboxybenzaldehyde 
• 117886-88-1 2-formyl benzoyl chloride 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 6295-21-2 3-chloro-1(3H)-isobenzofuranone 

Relevant academic research and scientific papers

Photoreactive Composition, Reaction Product, and Method of Producing Reaction Product

A photoreactive composition including a base-reactive compound, a photobase generator that is represented by the following Formula (1) and that generates a base when irradiated with light, and at least one compound selected from the group consisting of a

Development of a Rhodium(II)-Catalyzed Chemoselective C(sp3)-H Oxygenation

We report the first example of RhII-catalyzed chemoselective double C(sp3)-H oxygenation, which can directly transform various toluene derivatives into highly valuable aromatic aldehydes with great chemoselectivity and practicality. The critical combination of catalyst Rh(OAc)2, oxidant Selectfluor, and solvents of TFA/TFAA promises the successful delivery of the oxidation with satisfactory yields. A possible mechanism involving a unique carbene-Rh complex is proposed, and has been supported by both experiments and theoretical calculations.

Gold-catalyzed amide synthesis from aldehydes and amines in aqueous medium

An efficient gold-catalyzed amide synthesis from aldehydes and amines in aqueous medium under mild reaction conditions has been developed.

The investigation of nucleophilic reactions of 3 -bromo/chloro phthalide with amines

The reaction of 3-bromo/chloro phthalide 1a/b with secondary amines in polar solvents gives the corresponding amides of 2-formylbenzoic acid, while in nonpolar solvents gives 3-aminophthalides. The reaction of 1a/b with aromatic primary amines gives 3-arylaminophthalides, while with aliphatic primary amines 3-hydroxyphthalimidines are obtained.

Effect of Nucleophilicity and Leaving Group Ability on the SN2 Reactions of Amines with (Acyloxy)alkyl α-Halides: A Product Distribution Study

The course of the reaction of amines with (acyloxy)alkyl α-halides has been found to depend on the nucleophilicity of the amines and the leaving group ability of the halides.More nucleophilic amines tended to give acylated products 2 from the reaction while less nucleophilic amines gave alkylated products 3.The use of a better leaving group also tended to favor the formation of a greater amount of alkylated product.These results have been compared to the observations of Westaway on the effect of leaving group ability and nucleophilicity on the bond lengths in the transit ion state of SN2 reactions.In addition, secondary amines have been shown to cause the rearrangement of 2-formylbenzamides to 3-amino-1(3H)-isobenzofuranones.