84538-50-1Relevant academic research and scientific papers
Mild chemical and biological synthesis of donor-acceptor flanked reporter stilbenes: Demonstration of a physiological wittig olefination reaction
McLeod, David,McNulty, James
supporting information, p. 6127 - 6131,5 (2020/09/16)
Unprecedented chemoselectivity is reported for the Wittig olefination reaction leading to the formation of reporter stilbenes under physiological conditions.
The investigation of nucleophilic reactions of 3 -bromo/chloro phthalide with amines
Desai,Chaphekar,Samant
, p. 810 - 813 (2007/10/03)
The reaction of 3-bromo/chloro phthalide 1a/b with secondary amines in polar solvents gives the corresponding amides of 2-formylbenzoic acid, while in nonpolar solvents gives 3-aminophthalides. The reaction of 1a/b with aromatic primary amines gives 3-arylaminophthalides, while with aliphatic primary amines 3-hydroxyphthalimidines are obtained.
Effect of Nucleophilicity and Leaving Group Ability on the SN2 Reactions of Amines with (Acyloxy)alkyl α-Halides: A Product Distribution Study
Sloan, Kenneth B.,Koch, Suzanne A. M.
, p. 635 - 640 (2007/10/02)
The course of the reaction of amines with (acyloxy)alkyl α-halides has been found to depend on the nucleophilicity of the amines and the leaving group ability of the halides.More nucleophilic amines tended to give acylated products 2 from the reaction while less nucleophilic amines gave alkylated products 3.The use of a better leaving group also tended to favor the formation of a greater amount of alkylated product.These results have been compared to the observations of Westaway on the effect of leaving group ability and nucleophilicity on the bond lengths in the transit ion state of SN2 reactions.In addition, secondary amines have been shown to cause the rearrangement of 2-formylbenzamides to 3-amino-1(3H)-isobenzofuranones.
