84542-26-7Relevant articles and documents
Aldosterone Antagonists. 3. Synthesis and Activities of Steroidal 7α-(Alkoxycarbonyl)-15,16-methylene Spirolactones
Nickisch, Klaus,Bittler, Dieter,Laurent, Henry,Losert, Wolfgang,Nishino, Yukishige,et al.
, p. 509 - 513 (1990)
Several A- and D-ring substituted steroidal 7α-alkoxycarbonyl spirolactones were synthesized with the purpose of increasing the aldosterone antagonistic potency and reducing the endocrinological side effects relative to the standard drug spironolactone.It was found that the 15β,16β-methylene derivative 17 exhibited a 2-fold higher aldosterone antagonistic activity compared to either spironolactone or the 15,16-unsubstituted derivative 29 while showing remarkably reduced antiandrogenicity.