67372-69-4

Basic information

• Product Name: 6,7-DeMethylene-6,7-dehydro Drospirenone
• Synonyms: 6,7-DeMethylene-6,7-dehydro Drospirenone;(15α,16α,17α)-15,16-Dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-4,6,15-triene-21-carboxylic Acid γ-Lactone;17β-Hydroxy-15β,16β-Methylene-3-oxo-17α- pregna-4,6-diene-21-carboxylic Acid γ-Lactone
• CAS NO: 67372-69-4
• Molecular Formula: C23H28O3
• Molecular Weight: 352.46662
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 67372-69-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 6,7-DeMethylene-6,7-dehydro Drospirenone(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DeMethylene-6,7-dehydro Drospirenone(67372-69-4)
• EPA Substance Registry System: 6,7-DeMethylene-6,7-dehydro Drospirenone(67372-69-4)

Safety Data

• Hazardous Substances Data: 67372-69-4(Hazardous Substances Data)

Usage

Description

6,7-DeMethylene-6,7-dehydro Drospirenone, also known as Drospirenone EP Impurity D, is an intermediate compound in the synthesis of Drospirenone (D689500). It plays a crucial role in the production process of Drospirenone, a hormone used in various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
6,7-DeMethylene-6,7-dehydro Drospirenone is used as an intermediate in the synthesis of Drospirenone for the following reasons:
1. It contributes to the production of Drospirenone, a hormone with various pharmaceutical applications, including contraception and hormone replacement therapy.
2. As an impurity, it helps in the quality control and assurance of the final product, ensuring the safety and efficacy of Drospirenone-based medications.
3. Its presence in the synthesis process allows for the optimization of the production method, potentially leading to more cost-effective and efficient manufacturing of Drospirenone.

Upstream product

• 889676-41-9 17-hydroxy-15β,16β-methylene-3-oxo-17α-pregna-4,6-diene-21,21-dicarboxyIic acid ethyl ester γ-lactone 
• 108674-97-1 17α-(3-hydroxypropynyl)-15β,16β-methylene-5β-androst-6-ene-3β,5,17β-triol 
• 82543-15-5 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one 
• 943434-07-9 3-ethoxy-15β,16β-methylene-17α-pregn-3,5-diene-21,17-carbolactone 
• 108664-95-5 (3S,5R,8R,9S,10R,13S,14S,15S,16S,17S)-17-(3-Hydroxy-propyl)-10,13-dimethyl-1,3,4,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-2H-cyclopropa[15,16]cyclopenta[a]phenanthrene-3,5,17-triol 

Downstream Products

• 90457-65-1 dihydrospirorenone 
• 889652-31-7 17-hydroxy-6α,7α;15β,16β-bismethylene-3-oxo-17α-pregn-4-ene-21,21-carboxyIic acid γ-lactone 
• 84542-26-7 7α-(methoxycarbonyl)-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone 
• 89948-36-7 Mespirenone 

Relevant articles and documents

Epoxidation of 17-oxo-15,16-methylene steroids with sulfoxonium ylides

A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.

A PROCESS FOR THE PREPARATION OF 17-HYDROXY-6β,7β;15β,l6β-BISMETHYLENE-17α-PREGN-4-ENE-3-ONE-21-CARBOXYLIC ACID γ-LACTONE AND KEY-INTERMEDIATES FOR THIS PROCESS

The invention relates to a process for the preparation of 17-hydroxy-6β,7β;15β,16β- bismethylene-17α-pregn-4-ene-3-one-21-carboxylic acid γ-lactone of formula (I) as well as to key- intermediates for this process.