84545-70-0 Usage
Uses
Used in Pharmaceutical Industry:
N-((4-Chloromethyl)-2-thiozolyl)guanidine hydrochloride is used as an antihypertensive and vasodilator agent for its ability to block calcium channel activity in smooth muscle cells, resulting in the relaxation and dilation of blood vessels, which effectively lowers blood pressure.
Used in Cardiovascular Medicine:
In the treatment of cardiovascular diseases, N-((4-Chloromethyl)-2-thiozolyl)guanidine hydrochloride is utilized for its potential to improve blood flow and reduce the strain on the heart, contributing to the management and mitigation of various cardiac conditions.
Used in Neurological Applications:
N-((4-Chloromethyl)-2-thiozolyl)guanidine hydrochloride has shown promise as a therapeutic agent for conditions such as migraines, where it may help alleviate symptoms by influencing vascular and neural mechanisms involved in the condition's pathophysiology.
Used in Diabetic Neuropathy Treatment:
N-((4-Chloromethyl)-2-thiozolyl)guanidine hydrochloride is applied in managing diabetic neuropathy, potentially through its effects on nerve blood flow and the modulation of pain signals, offering relief from neuropathic pain associated with diabetes.
Used in Hypoxic-Ischemic Injury Therapy:
For conditions involving hypoxic-ischemic injury, this chemical compound is considered for its potential neuroprotective properties, which may aid in the recovery and protection of brain tissue following an ischemic event.
Check Digit Verification of cas no
The CAS Registry Mumber 84545-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,4 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84545-70:
(7*8)+(6*4)+(5*5)+(4*4)+(3*5)+(2*7)+(1*0)=150
150 % 10 = 0
So 84545-70-0 is a valid CAS Registry Number.
84545-70-0Relevant academic research and scientific papers
ONE-POT PREPARATION OF S-(GUANIDINO-4-YL-METHYL)-ISOTHIOUREA DIHYDROCHORIDE
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Page/Page column 5, (2010/02/10)
The invention relates to a new one pot preparation of N-[[4-(amino iminoethyl)thio]methyl]-2-thiozolyl]-guanidine dihydrochloride of formula (IV), by the reaction of 1, 3idiochloroacetone of formula (I) with gunadinothiourea of formula (II) and reacting the compound formed insitu (formula-III) with thiourea.
A process for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)propionitrile
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, (2008/06/13)
The present invention describes a beta-cyanoethylation process of thiol-compounds by acrylonitrile, for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)pro-pionitrile, in an aqueous-methanolic medium.
