84559-78-4

Basic information

• Product Name: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate
• Synonyms: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate
• CAS NO: 84559-78-4
• Molecular Weight: 394.468
• Mol File: 84559-78-4.mol

Chemical Properties

• CAS DataBase Reference: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate(84559-78-4)
• EPA Substance Registry System: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate(84559-78-4)

Safety Data

• Hazardous Substances Data: 84559-78-4(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 31202-69-4 N_ε-(tert-butoxycarbonyl)-D-lysine 
• 501-53-1 benzyl chloroformate 
• 66845-42-9 N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-D-lysine 
• 74-88-4 methyl iodide 

Downstream Products

• 110473-28-4 N-(benzyloxycarbonyl)-D-glutamyl-N'-(tert-butyloxycarbonyl)-D-lysine methyl ester 
• 110547-98-3 N-(benzyloxycarbonyl)-cyclo(D-glutamyl-D-lysyl) methyl ester 
• 110548-84-0 N-(benzyloxycarbonyl)-cyclo(D-glutamyl-D-lysyl) N'-methylamide 
• 110473-32-0 N-(benzyloxycarbonyl)-γ-(pentachlorophenyl)-D-glutamyl-D-lysine methyl ester, hydrochloride salt 
• 110473-30-8 N-(benzyloxycarbonyl)-γ-(pentachlorophenyl)-D-glutamyl-N'-(tert-butyloxycarbonyl)-D-lysine methyl ester 
• 84559-77-3 N-(D-valylleucyl-D-lysyl)-N',N'-bis(2-chloroethyl)-p-phenylenediamine bis(trifluoroacetate) 
• 84559-74-0 N-α-(tert-buthoxycarbonyl)-D-valylleucyl-N^ε-(tert-buthoxycarbonyl)-D-lysyl>-N',N'-bis(2-chloroethyl)-p-phenylenediamine 
• 66494-53-9 methyl N₆-(tert-butoxycarbonyl)-D-lysinate hydrochloride 
• 63328-49-4 (R)-2-amino-6-tert-butoxycarbonylaminohexanoic acid methyl ester 

Relevant articles and documents

FACTOR XIIa INHIBITORS

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Synthesis of a Novel Class of Peptides: Dilactam-Bridged Tetrapeptides

As model compounds for the study of constrained peptides, the following lactam-bridged derivatives were synthesized: Ac-L--D--NHMe (I), Ac-L--L--NHMe (II), Ac-L--NHMe (III), Ac-L--D--NHMe (IV), Ac-L--L--NHMe (V), and Ac-L--NHMe (VI).Benzyloxycarbonyl and tert-butyloxycarbonyl groups were employed for amine protection and the benzyl and methyl esters for carboxyl protection.Coupling reactions were carried out by the use of active esters or through azide activation.Cyclization reactions were carried out by adding the active ester hydrochlorides into large volumes of pyridine at elevated temperatures.The cyclic intermediates were obtained in yields of 45-50percent.Fragment condensation of the cyclic dipeptides yielded the corresponding dilactam-bridged tetrapeptides.