845609-54-3

Basic information

• Product Name: 4-[4-[2-(Cyclopropylmethoxy)-5-methylsulfonylbenzoyl]piperazin-1-yl]-3-fluorobenzonitrile
• Synonyms: 4-[4-[2-(Cyclopropylmethoxy)-5-methylsulfonylbenzoyl]piperazin-1-yl]-3-fluorobenzonitrile;Benzonitrile, 4-[4-[2-(cyclopropylMethoxy)-5-(Methylsulfonyl)benzoyl]-1-piperazinyl]-3-fluoro-
• CAS NO: 845609-54-3
• Molecular Formula: C23H24FN3O4S
• Molecular Weight: 458
• Mol File: 845609-54-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.41
• CAS DataBase Reference: 4-[4-[2-(Cyclopropylmethoxy)-5-methylsulfonylbenzoyl]piperazin-1-yl]-3-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-[2-(Cyclopropylmethoxy)-5-methylsulfonylbenzoyl]piperazin-1-yl]-3-fluorobenzonitrile(845609-54-3)
• EPA Substance Registry System: 4-[4-[2-(Cyclopropylmethoxy)-5-methylsulfonylbenzoyl]piperazin-1-yl]-3-fluorobenzonitrile(845609-54-3)

Safety Data

• Hazardous Substances Data: 845609-54-3(Hazardous Substances Data)

Upstream product

• 182181-38-0 3-fluoro-4-(piperazin-1-yl)benzonitrile 
• 845616-03-7 2-(cyclopropylmethoxy)-5-(methylsulfonyl)benzoic acid 

Relevant articles and documents

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

Screening of the Roche compound library led to the identification of the benzoylpiperazine 7 as a structurally novel GlyT1 inhibitor. The SAR which was developed in this series resulted in the discovery of highly potent compounds displaying excellent sele

BENZOYL-PIPERAZINE DERIVATIVES

The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.