845658-77-7Relevant academic research and scientific papers
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors
Waterson, Alex G.,Stevens, Kirk L.,Reno, Michael J.,Zhang, Yue-Mei,Boros, Eric E.,Bouvier, Frederic,Rastagar, Abdullah,Uehling, David E.,Dickerson, Scott H.,Reep, Bryan,McDonald, Octerloney B.,Wood, Edgar R.,Rusnak, David W.,Alligood, Krystal J.,Rudolph, Sharon K.
, p. 2419 - 2422 (2006)
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor appende
CHEMICAL COMPOUNDS
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Page/Page column 102-103, (2010/02/10)
The present invention discloses pyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such pyrimidine derivatives are useful in the treat
