Bioorganic and Medicinal Chemistry Letters p. 2419 - 2422 (2006)
Update date:2022-09-26
Topics:
Waterson, Alex G.
Stevens, Kirk L.
Reno, Michael J.
Zhang, Yue-Mei
Boros, Eric E.
Bouvier, Frederic
Rastagar, Abdullah
Uehling, David E.
Dickerson, Scott H.
Reep, Bryan
McDonald, Octerloney B.
Wood, Edgar R.
Rusnak, David W.
Alligood, Krystal J.
Rudolph, Sharon K.
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor appende
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