84570-80-9

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 1152-07-4 2-(4-methoxyphenyl)-3H-quinazolin-4-one 
• 98-80-6 phenylboronic acid 
• 62-53-3 aniline 
• 104-01-8 4-Methoxyphenylacetic acid 
• 100-58-3 phenylmagnesium bromide 
• 1885-29-6 anthranilic acid nitrile 
• 13141-38-3 2-phenylethynylaniline 
• 874-90-8 4-methoxybenzonitrile 
• 133349-85-6 1-(4''-methoxybenzyl)-1H-benzo[d][1.2.3]triazole 
• 84570-91-2 2-(4-Methoxy-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline 
• 153172-71-5 N-(2-cyanophenyl)-4-methoxybenzamide 

Relevant academic research and scientific papers

Fe3O4@Sap/Cu(ii): An efficient magnetically recoverable green nanocatalyst for the preparation of acridine and quinazoline derivatives in aqueous media at room temperature

Saponin, as a green and available phytochemical, was immobilized on the surface of magnetite nanoparticles then doped with Cu ions (Fe3O4@Sap/Cu(ii)) and used as an efficient nanocatalyst for the synthesis of quinazoline and acridine derivatives, due to t

A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions?

A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditio

TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines

A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.

Synthesis of quinazolines over recyclable Fe3O4@SiO2-PrNH2-Fe3+ nanoparticles: A green, efficient, and solvent-free protocol

A practical and efficient method is developed for efficient synthesis of quinazoline derivatives through condensation reaction of 2-aminoaryl ketone, an aldehyde, and ammonium acetate, over magnetic Fe3O4@SiO2-PrNH2/

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha

Heterogeneous oxidative synthesis of quinazolines over OMS-2 under ligand-free conditions

A manganese oxide octahedral molecular sieve (OMS-2) prepared using urea as an additive was found to be an efficient recyclable catalyst for the synthesis of quinazolines via oxidation/cyclization. A broad range of substituted quinazolines were obtained from alcohols and amidines in good yields under ligand-free conditions. OMS-2 was characterized by XRD, BET, ICP-AES, SEM, TEM and XPS, which indicated that the superior catalytic ability might arise from enhanced surface area and crystallinity.

Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen

A copper-catalyzed process for the synthesis of substituted quinazolines from benzonitriles and 2-ethynylanilines using molecular oxygen (O2) as sole oxidant is described. The mild catalytic system enabled the effective cleavage of the C-C triple bond and construction of new C-N and C-C bonds in one operation. Furthermore, the compound N,N-dimethyl-4-(2-(4-(trifluoromethyl)phenyl)quinazolin-4-yl)aniline (3dj) exhibited obvious aggregation-induced emission phenomenon, and the fluorescence quantum yield (ΦF,film) and lifetime (τfilm) were measured to be 45.5% and 5.8 ns in thin films state, respectively.

Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines

The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.