84570-82-1Relevant academic research and scientific papers
Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines
Hu, Kun,Zhen, Qianqian,Gong, Julin,Cheng, Tianxing,Qi, Linjun,Shao, Yinlin,Chen, Jiuxi
, p. 3083 - 3087 (2018)
The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.
Catalyst-free synthesis of quinazoline derivatives using low melting sugar-urea-salt mixture as a solvent
Zhang, Zhan-Hui,Zhang, Xiao-Nan,Mo, Li-Ping,Li, Yong-Xiao,Ma, Fei-Ping
experimental part, p. 1502 - 1506 (2012/06/04)
Low melting mixture of maltose-dimethylurea (DMU)-NH4Cl was found to be an inexpensive, non-toxic, easily biodegradable and effective reaction medium in the catalyst-free synthesis of quinazoline derivatives. This simple and efficient method fu
Transformation of 5,5-diaryl-4,5-dihydro-1,2,4-oxadiazoles to 4-arylquinazolines
Szczepankiewicz, Wojciech,Wagner, Pawe?,Danicki, Miros?aw,Suwiński, Jerzy
, p. 2015 - 2017 (2007/10/03)
The transformation of 5,5-diaryl-4,5-dihydro-1,2,4-oxadiazoles to 4-arylquinazolines in boiling acetic anhydride via acyclic 1-acetyloxy-4-aryl-1,3-diaza-1,3-butadienes is described.
