84571-09-5

Basic information

• Product Name: Quinazoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-
• CAS NO: 84571-09-5
• Molecular Formula: C14H13N3O2
• Molecular Weight: 255.276
• Mol File: 84571-09-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Quinazoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-(84571-09-5)
• EPA Substance Registry System: Quinazoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-(84571-09-5)

Safety Data

• Hazardous Substances Data: 84571-09-5(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 4403-69-4 2-amino-1-benzylamine 
• 197524-51-9 (2-Azido-benzyl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 96308-13-3 2-azidobenzylamine 
• 140429-25-0 N-pyridinium chloride 

Relevant articles and documents

Gold(0) catalyzed dehydrogenation of N-heterocycles

Gold nanoclusters are good catalyst precursors for the catalytic dehydrogenation of indolines, tetrahydroquinazolines, and related N-heterocycles. The catalytically active species is presumably Au(0) nanoparticles.

Laccase-Based Oxidative Catalytic Systems for the Aerobic Aromatization of Tetrahydroquinazolines and Related N-Heterocyclic Compounds under Mild Conditions

In this work, for the first time, laccase (metalloenzyme)/3,5-di-tert-butylcatechol (DTBC) as a new class of bioinspired quinone-based cooperative catalytic oxidation system and laccase/2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) catalyst system were used for the aerobic oxidative synthesis of 2-substituted quinazolines through cascade reaction of structurally divers aldehydes with 2-aminobenzylamine. The products were obtained in good to high yields in phosphate buffer (0.1 m, 12.5 mL, pH = 4.5) and acetonitrile (4 vol.-%) mixture as solvent at 45 °C. Other N-heterocycles are also successfully oxidized to their aromatic counterparts.

CuCl/DABCO/4-HO-TEMPO-catalyzed aerobic oxidative synthesis of 2-substituted quinazolines and 4 H -3,1-benzoxazines

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.